Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 581-590 of 639 results
Neural Regeneration Research, 2018 • September 1, 2018
The study investigated the protective effect of apocynin, a NOX inhibitor, in rat diabetic neuropathy. Streptozotocin-induced diabetic rats were treated with apocynin for 4 weeks, and mechanical hyper...
KEY FINDING: Streptozotocin injection reduced pain threshold in analgesimeter, but not in aesthesiometer, in rat models. Apocynin treatment increased pain threshold dose-dependently.
PLoS ONE, 2018 • August 23, 2018
This study investigated the potential of Tanshinone IIA, a component of Danshen, to promote nerve regeneration after sciatic nerve crush injury in rats. The administration of Tanshinone IIA resulted i...
KEY FINDING: Tanshinone IIA improved motor function after nerve crush injury, as indicated by increased SFI values.
Scientific Reports, 2018 • September 4, 2018
This document is an author correction to a previously published article in Scientific Reports. The corrections address typographical errors and inaccuracies in the Introduction, Materials and Methods,...
KEY FINDING: The correction clarifies that the rapid biological clearance of agents from the body is due to degradation, reinforcing the need for biodegradable scaffolds.
Scientific Reports, 2018 • August 7, 2018
The study successfully delivered IFN-α mRNA to human skin explants using biolistic application. Optimized IFN-α mRNA sequence variants resulted in significantly higher IFN-α protein expression compare...
KEY FINDING: Skin explants remained viable and intact for at least five days, making them suitable for testing.
Theranostics, 2018 • August 7, 2018
This study introduces a novel multi-drug delivery system for spinal cord injury (SCI) repair, utilizing scar-homing liposomes loaded with docetaxel (DTX) and growth factors (GFs) embedded in a thermos...
KEY FINDING: The scar-homing liposomes (CAQK-LIPs) specifically bind to the lesion site after SCI, enabling targeted drug delivery.
Mol Neurobiol, 2019 • June 1, 2019
This study aimed to identify pharmacological enhancers of axon regeneration using an in vitro cortical scrape assay. A compound library was screened, and diltiazem, verapamil, and bromopride were foun...
KEY FINDING: Diltiazem, verapamil, and bromopride were identified as compounds that facilitate axon regeneration in rat cortical cultures in the presence of CSPGs.
Adv. Sci., 2018 • July 23, 2018
The study introduces DeepScreen, a deep learning-based drug screening system utilizing convolutional neural networks and flow cytometry single-cell images, to address the limitations of traditional me...
KEY FINDING: DeepScreen demonstrates high accuracy in assessing the efficacy of drugs and nanoformulated drug systems, achieving accuracies of 0.851, 0.864, and 0.908 in testing mixed cells, HEpG2, and A549 cells, respectively.
Regenerative Therapy, 2018 • October 3, 2018
Magnetic targeting is a cell delivery system that utilizes magnetic labeling of cells and a magnetic field to achieve minimally invasive cell transplantation. The technique has shown promise in animal...
KEY FINDING: Magnetic targeting enhances the infiltration of MSCs into artificial bone and bone formation in rabbit forelimb bone defect model.
J Neurotrauma, 2021 • February 1, 2021
This study investigates the effects of low-dose, site-directed estrogen delivery via nanoparticles on spinal cord injury (SCI) in rats. The researchers hypothesized that this method would reduce infla...
KEY FINDING: Site-directed estrogen delivery reduced lesion size, reactive gliosis, and glial scar formation compared to controls.
Theranostics, 2018 • October 27, 2018
This study identifies new translational targets for PET tracers that can image the anti-inflammatory/protective activation state of microglia. The study demonstrates the potential of a rationale-based...
KEY FINDING: P2RY12 expression increases in murine and human microglia following exposure to anti-inflammatory stimuli.