Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 571-580 of 639 results
JOURNAL OF NEUROTRAUMA, 2018 • March 15, 2018
The study aimed to determine if rapamycin (RAP) could modulate autonomic dysreflexia (AD) development after spinal cord injury (SCI) by impeding intraspinal plasticity. RAP was administered to naïve ...
KEY FINDING: Rapamycin significantly elevated resting blood pressure in rats with SCI, with average daily blood pressure rising above even normal naïve levels within one week after injury.
SCIENTIFIC REPORTS, 2018 • January 29, 2018
The study uses a systems biology approach and artificial intelligence to identify NeuroHeal, a neuroprotective drug combination for peripheral nerve root avulsion. NeuroHeal, consisting of acamprosate...
KEY FINDING: NeuroHeal, a combination of acamprosate (ACA) and ribavirin (RIB), promotes neuroprotection, nerve regeneration, and functional recovery.
Neural Regeneration Research, 2018 • January 1, 2018
This study investigated the potential synergistic neuroprotective effects of combined curcumin and EGCG therapy in a rat model of acute spinal cord injury. While both curcumin and EGCG, alone or in co...
KEY FINDING: Curcumin and EGCG alone or in combination resulted in significant behavioral recovery after spinal cord injury in rats, as measured by the BBB open-field locomotor test.
Frontiers in Pharmacology, 2018 • April 10, 2018
This study evaluated the effectiveness of adipose-derived mesenchymal stem cells (AD-MSCs) combined with a fibrin matrix in promoting structural and functional recovery following spinal cord injury (S...
KEY FINDING: The application of AD-MSCs combined with fibrin matrix significantly improved motor function in rats with SCI, as demonstrated by higher BBB locomotor scores compared to the control group.
Toxins, 2018 • March 18, 2018
This study aimed to verify if BoNT/B is able to counteract neuropathic pain, and to interfere with inflammatory and regenerative processes associated with nerve injury. The results of this study show ...
KEY FINDING: BoNT/B reduces neuropathic pain over a long period of time, similar to BoNT/A.
Frontiers in Neuroscience, 2018 • April 23, 2018
This study investigated the therapeutic potential of platelet-rich plasma (PRP) for spinal cord injuries (SCI) in rats. PRP was administered intrathecally (i.t.) to both normal and SCI rats. The resul...
KEY FINDING: In rats with SCIs, i.t. PRP enhanced the locomotor recovery and spared white matter, promoted angiogenesis and neuronal regeneration, and modulated blood vessel size.
British Journal of Pharmacology, 2018 • January 1, 2018
This study investigates the analgesic effects of ASP3662, a novel 11β-HSD1 inhibitor, in rat models of neuropathic and dysfunctional pain. ASP3662 is a potent, selective, and CNS-penetrable inhibitor ...
KEY FINDING: ASP3662 effectively inhibits 11β-HSD1 in humans, mice, and rats, demonstrating selectivity over 11β-HSD2 and showing no significant impact on other enzymes, transporters, and receptors.
International Journal of Nanomedicine, 2018 • January 1, 2018
This study introduces a novel drug delivery system utilizing dextran-based biodegradable nanoparticles to deliver paclitaxel (PTX) for treating traumatic spinal cord injury (SCI). The PTX@Ac-DEX nanop...
KEY FINDING: The prepared PTX-loaded Ac-DEX nanoparticles promoted neurite extension in the presence of CSPGs, suggesting a potential for overcoming inhibitory factors after SCI.
Nature, 2018 • August 1, 2018
This study elucidates a unifying mechanism for small-molecule enhancers of oligodendrocyte formation: the elevation of 8,9-unsaturated sterol intermediate levels via inhibition of cholesterol biosynth...
KEY FINDING: A broad range of pro-myelinating small molecules function by directly inhibiting CYP51, TM7SF2, or EBP, enzymes within the cholesterol biosynthesis pathway.
Frontiers in Neuroscience, 2018 • July 19, 2018
Recent studies have demonstrated that delivery of protein therapeutics to the spinal cord may promote functional axon regeneration, providing a pathway for recovery of certain motor skills. This persp...
KEY FINDING: Inducing axon regeneration is possible, as a 2010 study found that mice treated with IGF-1 displayed significant gains in axon number and diameter following peripheral nerve injury.