Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 521-530 of 639 results
Scientific Reports, 2015 • March 12, 2015
This study investigates the potential of a bFGF-incorporated HEMA-MOETACL hydrogel implant to repair spinal cord injuries (SCI) in rats. The results demonstrate that the bFGF/HEMA-MOETACL transplant p...
KEY FINDING: The bFGF/HEMA-MOETACL transplant provided a scaffold for the ingrowth of regenerating tissue eight weeks after implantation.
Drug Design, Development and Therapy, 2015 • April 17, 2015
This study demonstrates that GSNO stimulates neurorepair processes, promotes angiogenesis, and aids functional recovery in rats after experimental stroke. GSNO's beneficial effects are mediated throug...
KEY FINDING: GSNO treatment enhanced the expression of HIF-1α, VEGF, and PECAM-1, which are neurorepair mediators, in rats after a stroke.
ACS Chem Biol., 2015 • August 21, 2015
The study developed a novel approach combining phenotypic screening with biochemical enzyme assays to systematically identify multiple biological targets relevant to neurite outgrowth. The strategy id...
KEY FINDING: Compounds that inhibit multiple targets (polypharmacology) promote robust neurite outgrowth in vitro.
Reprod Toxicol., 2015 • August 15, 2015
This study investigated the blood-CSF barrier in nonhuman primate fetuses during the second half of gestation, focusing on tight junctions and enzymes/transporters involved in xenobiotic metabolism an...
KEY FINDING: There were no differences in the expression of the tight-junctions at the CP suggesting a well-formed fetal blood-CSF barrier during this period of gestation.
Comp Biochem Physiol C Toxicol Pharmacol, 2015 • December 1, 2015
The study introduces a new tail regeneration model using late-stage Mexican axolotl embryos, which can regenerate amputated tails in 7 days. Chemical screening identified Wnt, transforming growth fact...
KEY FINDING: Axolotl embryos can completely regenerate amputated tails in 7 days without feeding, making them an efficient model for regeneration studies.
PLoS ONE, 2015 • November 12, 2015
This study demonstrates that prolonged subdural infusion of KYNA in rats leads to dose-dependent myelin damage in the spinal cord. The myelin damage is characterized by the separation of myelin lamell...
KEY FINDING: Continuous subdural KYNA infusion causes dose-dependent myelin damage and myelin loss in the rat spinal cord.
Neural Regeneration Research, 2015 • September 1, 2015
The study aimed to determine if combining Schwann cell transplantation and hyperbaric oxygen therapy provides superior recovery from spinal cord injury compared to individual treatments. Rat models of...
KEY FINDING: The combined treatment of Schwann cell transplantation and hyperbaric oxygen therapy was more effective in improving hindlimb motor function than either treatment alone.
Neural Regeneration Research, 2015 • November 1, 2015
This study investigates the potential synergistic effect of combining fasudil (a ROCK inhibitor) and celecoxib (a COX-2 inhibitor) on spinal cord injury recovery in rats. The results demonstrate that ...
KEY FINDING: The combined use of celecoxib and fasudil significantly decreased COX-2 and Rho kinase II expression surrounding the lesion site in rats with spinal cord injury.
Acta Biomater, 2016 • April 15, 2016
The study introduces a novel cationic amphiphilic copolymer, poly (lactide-co-glycolide)-graft-polyethylenimine (PgP), as an efficient nonviral vector for nucleic acid delivery to the spinal cord. PgP...
KEY FINDING: PgP micelles efficiently transfect pDNA and siRNA in the presence of 10% serum in neuroglioma (C6) cells, neuroblastoma (B35) cells, and primary E8 chick forebrain neurons (CFN).
Neural Regeneration Research, 2015 • December 1, 2015
This special issue provides an overview of current research on spinal cord injury repair, protection, and regeneration. It highlights several promising therapeutic strategies, including biomaterials, ...
KEY FINDING: Nanodrug-coated stents can improve axon regeneration after spinal cord injury.