Neural Regeneration Research, 2015 · DOI: 10.4103/1673-5374.172314 · Published: December 1, 2015
This special issue of Neural Regeneration Research focuses on the repair, protection, and regeneration of the spinal cord after injury. It covers various approaches, including nanodrug-coated stents, macrophage polarization, RhoA signaling inhibition, and microsurgical lysis. The issue also explores the use of olfactory ensheathing cells, optogenetics, zinc, and electroactive scaffolds to promote recovery after spinal cord injury.
Development of advanced biomaterials, such as nanodrug-coated stents and electroactive scaffolds, can provide structural support and promote axon regeneration after spinal cord injury.
Targeting immune cells, such as macrophages and T lymphocytes, to modulate the inflammatory response and promote neuroprotection can improve outcomes after spinal cord injury.
Identifying and repurposing existing drugs that can inhibit specific signaling pathways, such as RhoA, or promote neurotrophic factor expression can accelerate the development of effective treatments for spinal cord injury.