Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 531-540 of 639 results
JOURNAL OF NEUROTRAUMA, 2016 • September 15, 2016
This study investigates the therapeutic potential of tamoxifen (TAM) in treating spinal cord injury (SCI) in female rats, focusing on its efficacy when administered up to 24 hours post-injury. The key...
KEY FINDING: Tamoxifen treatment, whether administered immediately or 24 hours after SCI, significantly improved functional locomotor recovery in rats.
PLoS ONE, 2016 • April 6, 2016
This study identifies and characterizes two potent and selective arylsulfonamide Nav1.7 inhibitors, PF-05198007 and PF-05089771, to investigate Nav1.7's role in nociceptor physiology. The findings dem...
KEY FINDING: Nav1.7 is the predominant functional TTX-sensitive Nav in mouse and human nociceptors, contributing to the initiation and upstroke phase of the nociceptor action potential.
Neural Regeneration Research, 2016 • March 1, 2016
This study investigates the neuroprotective effects of Salvianolic acid B (Sal B) on the myelin sheath after spinal cord injury (SCI). In vitro results demonstrated that Sal B contributes to oligodend...
KEY FINDING: Salvianolic acid B (Sal B) promotes the maturation and differentiation of oligodendrocyte precursor cells in vitro.
Current Neuropharmacology, 2016 • May 2, 2016
This review explores the theoretical and practical implications of the brain-gut axis, focusing on the stable gastric pentadecapeptide BPC 157 and its potential as a remedy in various CNS disorders. B...
KEY FINDING: BPC 157 exhibits neuroprotective effects, improving nerve regeneration after peripheral nerve transection and counteracting autotomy.
Neural Regeneration Research, 2016 • April 1, 2016
This study investigates the effect of senegenin on neuronal apoptosis and functional recovery after spinal cord contusion injury in rats. Senegenin, the main bioactive ingredient in thinleaf milkwort ...
KEY FINDING: Senegenin reduced the size of syringomyelic cavities in the spinal cord, indicating a protective effect against tissue damage.
Frontiers in Pharmacology, 2016 • May 9, 2016
This study investigates the mechanisms behind the differing regenerative capabilities after spinal cord injury (SCI) between mammals and non-mammalian vertebrates, focusing on zebrafish. Comparative t...
KEY FINDING: Genes related to cell cycle were significantly enriched in genes specifically dysregulated in zebrafish SCI.
Acta Orthopaedica, 2016 • July 1, 2016
This study evaluated the effect of a single dose of erythropoietin (EPO) on bone healing in a rabbit long-bone defect model. EPO was administered either locally to the defect or systemically during su...
KEY FINDING: Both local and systemic EPO treatment significantly increased bone formation compared to the control group. Specifically, bone formation was 2.3 to 2.5 times greater in the treatment groups after 12 weeks.
Clinics, 2016 • June 1, 2016
This study evaluated the effects of ganglioside G(M1) and erythropoietin on functional and histological outcomes after spinal cord injury in rats. The combined administration of G(M1) and erythropoiet...
KEY FINDING: The erythropoietin group had higher BBB scores than the G(M1) group, indicating better motor function recovery.
Neural Regeneration Research, 2016 • June 1, 2016
This study investigates the effects of atorvastatin on neurological function recovery after spinal cord injury (SCI) in rats. The researchers hypothesized that atorvastatin could activate autophagy, a...
KEY FINDING: Atorvastatin significantly up-regulated Beclin-1 and LC3B gene and protein expression after SCI, suggesting that atorvastatin activated autophagy.
Neural Regeneration Research, 2016 • August 1, 2016
This study investigated the effects of curcumin on peripheral nerve regeneration following complete sciatic nerve amputation in mice. The mice were administered different doses of curcumin for one wee...
KEY FINDING: High and moderate doses of curcumin significantly improved the action potential amplitude of the sciatic nerves and the conduction velocity of motor neurons.