Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 31-40 of 639 results
Neural Regeneration Research, 2014 • March 1, 2014
This study investigated the effects of puerarin on neural regeneration after sciatic nerve injury in mice. Puerarin was administered at different doses, and its impact on GAP43 expression, muscle atro...
KEY FINDING: Puerarin at middle and high doses significantly up-regulated the expression of growth-associated protein 43 in the L4–6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling.
Neural Regeneration Research, 2012 • December 1, 2012
This study aimed to analyze the delivery of a novel liposome and its ability to transport drugs across the blood-spinal cord and blood-brain barriers. The novel liposomes have a hydrophobic core for e...
KEY FINDING: The modified liposomes exhibited good biocompatibility and low cytotoxicity when cocultured with human breast adenocarcinoma cells.
World J Orthop, 2015 • January 18, 2015
A number of studies on surgical timing suggest that early surgical intervention is safe and feasible, can improve clinical and neurological outcomes and reduce health care costs, and minimize the seco...
KEY FINDING: Early surgical intervention is safe and feasible, can improve clinical and neurological outcomes and reduce health care costs.
Neural Regen Res, 2014 • December 1, 2014
This study explored the mechanisms associated with the recovery of neurological function after hyperbaric oxygen therapy in a rat model of spinal cord injury. Our findings indicate that hyperbaric oxy...
KEY FINDING: Hyperbaric oxygen therapy reduces apoptosis in the injured spinal cord tissue of rats.
Neural Regen Res, 2012 • February 1, 2012
This study investigates the effect of 7, 8-dihydroxycoumarin on peripheral nerve regeneration and functional recovery in a mouse model of sciatic nerve injury. The results indicate that 7, 8-dihydroxy...
KEY FINDING: 7, 8-dihydroxycoumarin upregulated GAP-43 protein expression in the L4-6 segments of the injured side in mice with sciatic nerve injury.
Biomedicines, 2014 • October 31, 2014
HGF was molecularly cloned as a growth factor for hepatocytes. The scatter factor, originally identified as a fibroblast-derived cell motility factor for epithelial cells, was shown to be an identical...
KEY FINDING: The intravenous/systemic administration of recombinant HGF protein has been well tolerated in phase I/II clinical trials.
Acute and Critical Care, 2025 • February 1, 2025
This paper presents two case reports detailing the successful use of droxidopa to manage hypotension in acute spinal cord injury (SCI) patients who could not tolerate midodrine due to reflex bradycard...
KEY FINDING: Droxidopa was successfully used to manage hypotension in two patients with acute SCI who experienced bradycardia with midodrine.
Chinese Journal of Traumatology, 2024 • May 12, 2023
This review examines the use of hyperbaric oxygen therapy (HBOT) for spinal cord injury (SCI), focusing on treatment protocols and critical issues in the existing literature. The review highlights the...
KEY FINDING: A meta-analysis suggests HBOT might be a safe, promising, and effective choice to limit secondary injury in SCI when started appropriately.
International Journal of Surgery, 2025 • June 24, 2024
This prospective, double-blind, randomized controlled study evaluated the safety and efficacy of intrawound vancomycin powder in preventing surgical site infections (SSIs) after posterior lumbar inter...
KEY FINDING: The study found an 87.5% decrease in the surgical site infection (SSI) rate in the vancomycin group compared to the control group.
Molecular Neurobiology, 2025 • September 4, 2024
This study investigates the potential of Curculigoside (CUR) to promote spinal cord tissue recovery following spinal cord injury (SCI) by mitigating oxidative stress and apoptosis. The results demonst...
KEY FINDING: CUR significantly reduced the expression of apoptosis-related proteins (Bax and Caspase-3) and increased the expression of the anti-apoptotic protein Bcl-2.