7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury

This study investigates the potential of 7, 8-dihydroxycoumarin to aid in nerve repair using a mouse model of sciatic nerve injury. The researchers found that 7, 8-dihydroxycoumarin increased the expression of growth associated protein 43 (GAP-43) in the spinal cord segments related to the injured nerve. The treatment also improved nerve function and the physical appearance of the nerve fibers, suggesting it could help in nerve regeneration.

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  7, 8-dihydroxycoumarin upregulated GAP-43 protein expression in the L4-6 segments of the injured side in mice with sciatic nerve injury.
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  7, 8-dihydroxycoumarin promoted neurological function in mice with sciatic nerve injury, increasing the amplitude and velocity of motor nerve conduction.
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  7, 8-dihydroxycoumarin improved the histological changes in the injured region, showing more regular myelin sheath appearance.