Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 41-50 of 639 results
IBRO Neuroscience Reports, 2024 • September 5, 2024
The study aimed to explore the potential therapeutic effects of irisin on chronic neuralgia and related affective disorders in a CCI mice model. The results indicated that irisin treatment could allev...
KEY FINDING: Irisin treatment ameliorated CCI-induced mechanical allodynia, thermal hyperalgesia, depressive, and anxiety behaviors in mice.
Neurochemical Research, 2025 • November 30, 2024
The study developed a novel slow-release nanoparticle estrogen (SNP-E2) delivery system that provides sustained release of E2 in the injured spinal cord without systemic exposure. Delivery of E2 via S...
KEY FINDING: SNP-E2 delivery reduced inflammation and gliosis, and induced microglial differentiation of M1 to M2 in rats after SCI.
J Clin Invest, 2025 • December 10, 2024
The study identifies C2230 as a state- and use-dependent CaV2.2 channel blocker, meaning it preferentially inhibits channels that are frequently activated or in an inactivated state. C2230 was shown t...
KEY FINDING: C2230 inhibits CaV2.2 channels in rat, marmoset, and human neurons in a G-protein-coupled-receptor–independent manner.
Brain and Behavior, 2024 • November 23, 2024
This study reveals that HBOT facilitates functional and structural plasticity in the brain, contributing to the recovery of motor function in rats with SCI. Following SCI, reduced ReHo values were obs...
KEY FINDING: Following SCI, reduced ReHo values were observed in the left primary somatosensory cortex, left striatum, right agranular insular cortex, and partial cortex in the limbic system, which was reversed after HBOT.
Journal of Cellular and Molecular Medicine, 2024 • November 26, 2024
This study investigated the protective effects of quercetin, a compound found in the Chinese herbal formula Jisuikang (JSK), on spinal cord injury (SCI). The research used network pharmacology to iden...
KEY FINDING: Quercetin, a key ingredient in Jisuikang (JSK), protects microglial cells from LPS-induced inhibition of cell viability and cellular inflammation.
Heliyon, 2024 • November 28, 2024
This study investigates the therapeutic potential of Tanshinone IIA (Tan IIA) in treating spinal cord injury induced by fluoride exposure in rats. The findings indicate that fluoride exposure leads to...
KEY FINDING: Fluoride exposure induces spinal cord injury with aberrant biomarkers, including increased mRNA levels of Mmp9, TNF-α, IL-1β, Mag, P53, NF-κB, and GSK3β, and decreased mRNA levels of Mbp.
CNS Neuroscience & Therapeutics, 2025 • January 1, 2025
The study aimed to understand how NDSM, known for analgesic efficacy, works to relieve pain, focusing on GABAA receptors and neuroinflammation. The results indicate that NDSM's analgesic effects are p...
KEY FINDING: NDSM demonstrates significant analgesic effects against chronic pain in both pain-evoked and pain-suppressed behavioral assays.
Cell Biol Toxicol, 2025 • January 1, 2025
This study investigates the effect of Comp 6d, a novel SIRT1 activator, on neuropathic pain and explores its mechanisms. The findings suggest that Comp 6d alleviates neuropathic pain by specifically a...
KEY FINDING: Comp 6d alleviates neuropathic pain by specifically activating SIRT1 in the spinal cord, as demonstrated by the abolishment of its effects in SIRT1 knockout mice.
Immunity, Inflammation and Disease, 2025 • January 1, 2025
This study investigates the potential of Isosteviol sodium (STVNa) to promote neurological function recovery in a rat model of spinal cord injury (SCI). The results demonstrate that STVNa improves loc...
KEY FINDING: STVNa improved spinal cord functional recovery in rats, evidenced by enhanced BBB locomotor rating scale and angle of inclination.
Molecules, 2025 • December 29, 2024
This study explores the gastroprotective effects of methyl eugenol (ME) in a rat model of spinal cord injury (SCI). SCI often leads to gastric ulceration, and current treatments have adverse effects. ...
KEY FINDING: Methyl eugenol exhibits a dose-dependent gastroprotective effect against gastric damage induced by spinal cord injury in rats.