Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 21-30 of 639 results
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2013 • July 17, 2013
This study aimed to determine if FK506 and NGF had a synergistic effect on the recovery of spinal cord functions in rats with acute spinal cord injury. The results demonstrated that the combined treat...
KEY FINDING: The combined treatment of FK506 and NGF significantly enhanced the expression of NF200 in rats with spinal cord injury.
ASN NEURO, 2013 • November 11, 2013
Traumatic injury or disease of the spinal cord and brain elicits multiple cellular and biochemical reactions that together cause or are associated with neuropathology. Ligands that target PPARs (perox...
KEY FINDING: PPAR activation inhibits the expression of M1 genes in cells exposed to M1-type stimuli and enhances the expression of M2 markers in the presence of M2 stimuli.
PLoS ONE, 2013 • December 13, 2013
This study successfully isolated a recombinant antibody fragment (scFv) that binds to NCAM1-expressing cells in the intervertebral disc (IVD). This scFv has potential applications in targeted drug del...
KEY FINDING: A human scFv was successfully isolated against the recombinant NCAM1 domain using phage display technology.
Exp Neurol, 2014 • November 1, 2014
This study replicated some, but not all, of the previously reported benefits of Taxol in rat models of spinal cord injury. Taxol was found to reduce fibrotic scarring in both dorsal hemisection (DHx) ...
KEY FINDING: Taxol significantly reduced scarring at the injury site after dorsal spinal hemisection (DHx).
Biomaterials, 2014 • October 1, 2014
The study investigates the potential of thrombin inhibitors to improve cellular regeneration after spinal cord injury. PLGA microspheres and Pluronic F-127 hydrogels were used to create depot formulat...
KEY FINDING: Thrombin increases endogenous neural progenitor proliferation in the intact murine spinal cord.
Fluids and Barriers of the CNS, 2014 • August 25, 2014
The study aimed to determine if bacterial melanin (BM) can cross the blood-brain barrier (BBB) in rats. Radioactively labeled BM was injected into rats, and its uptake in various tissues, including th...
KEY FINDING: Radioactively-labeled bacterial melanin crosses the blood–brain barrier and is enzymatically stable in blood and brain parenchyma.
Neural Regen Res, 2013 • December 1, 2013
This study investigated the protective effect of curcumin on ischemic spinal cord injury in rats. Spinal cord ischemia models were created by ligating the lumbar artery, and curcumin was administered ...
KEY FINDING: Curcumin significantly improved motor function of the rat hind limb after spinal cord ischemia.
Neural Regen Res, 2013 • February 1, 2013
This study investigates the impact of methylprednisolone on Nogo-A expression in rats with acute spinal cord injuries induced by the weight-drop method. The findings reveal that spinal cord injury ele...
KEY FINDING: Spinal cord injury in rats led to reduced motor behavior ability and necrotic injury in spinal cord tissues, accompanied by increased Nogo-A expression.
Neural Regeneration Research, 2014 • May 1, 2014
This study investigated the analgesic effect of bumetanide, a specific sodium-potassium-chloride co-transporter 1 (NKCC1) inhibitor, and the change in spinal NKCC1 and potassium-chloride co-transporte...
KEY FINDING: Intrathecal bumetanide could decrease cumulative pain scores, and could increase thermal and mechanical pain thresholds in a rat model of incisional pain.
Neural Regeneration Research, 2014 • February 1, 2014
This study explored the use of amino-functionalized multi-walled carbon nanotubes (MWCNTs) to deliver nerve growth factor (NGF). The researchers prepared MWCNTs-NGF complexes and assessed their physic...
KEY FINDING: Amino functionalization improves the dispersibility of carbon nanotubes-nerve growth factor complexes.