Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 281-290 of 639 results
Pharmacol Res Perspect, 2022 • April 9, 2022
The study investigates the paralytic effects of a novel botulinum toxin A (A/Chin) on rat gastrocnemius muscle, comparing its efficacy and duration to other BTX-A formulations with and without complex...
KEY FINDING: A/Chin demonstrates a rapid and consistent time-to-peak paralytic effect, reaching its peak on day 3 post-injection.
Frontiers in Microbiology, 2022 • May 10, 2022
This study developed phage cocktails effective against E. coli strains isolated from urine of patients with spinal cord injury (SCI), which exhibit strong biofilm-forming properties, addressing the cha...
KEY FINDING: Nine phages were identified that individually decreased cell viability by >80% when added to biofilms of two E. coli strains in human urine.
Spinal Cord Series and Cases, 2022 • April 7, 2022
This case report highlights an instance of transient alterations in consciousness in a 43-year-old male with spinal cord injury following baclofen initiation, which resolved upon baclofen discontinuat...
KEY FINDING: Baclofen can cause transient alterations of consciousness in SCI patients, mimicking orthostatic hypotension.
Journal of Nanobiotechnology, 2022 • June 4, 2022
The study introduces a novel biomimetic synthesis method for ultrasmall Pd nanoclusters (Pd@insulin) using insulin as a template, demonstrating its effectiveness in scavenging ROS and improving outcom...
KEY FINDING: Insulin-incubated palladium clusters (Pd@insulin) were successfully synthesized using a green biomimetic method and exhibited excellent multiple ROS-scavenging ability.
NeuroReport, 2022 • January 1, 2022
This study investigates the neuroprotective effect of Notoginsenoside R1 (NGR1) in rats with spinal cord injury (SCI) and its underlying mechanism. Results demonstrate that NGR1 administration reduces...
KEY FINDING: NGR1 administration enhances neurological function and mitigates tissue damage and motor neuron loss after SCI compared to the vehicle group.
Frontiers in Endocrinology, 2022 • June 20, 2022
This study investigates the interaction between melanocortin 1 receptor (Mc1r) and melanocortin receptor-associated proteins (Mraps) in Xenopus tropicalis. The research combines in silico analysis wit...
KEY FINDING: xtMc1r interacts directly with xtMrap1 and xtMrap2 proteins on the plasma membrane, validated through co-immunoprecipitation and fluorescence.
Frontiers in Pharmacology, 2022 • July 8, 2022
This study investigates the neuroprotective effects of catalpol (CAT) on spinal cord injury (SCI) in rats. The research demonstrates that CAT promotes functional recovery in SCI rats by inhibiting ER ...
KEY FINDING: CAT has a restorative effect on the lower limb motor function of rats with SCI.
Spine Surg Relat Res, 2022 • December 27, 2021
This multicenter study investigated whether antiplatelet/anticoagulant (APAC) drugs affect blood loss during surgery for cervical spine trauma in elderly patients. The study found no significant incre...
KEY FINDING: APAC use in elderly patients was not significantly associated with surgical blood loss according to the IPTW method with propensity scoring or linear mixed model analyses.
Frontiers in Neuroscience, 2022 • August 11, 2022
This systematic review examined the efficacy of metformin in treating spinal cord injuries (SCI) in rats. The review included 12 studies and analyzed the effects of metformin on neurological function ...
KEY FINDING: Metformin treatment was associated with increased Basso, Beattie, and Bresnahan (BBB) scores, indicating improved locomotor function in rats with SCI.
Neuropsychopharmacology, 2022 • September 30, 2022
This article is a correction to a previously published study concerning the association of GFAP concentration and posttraumatic stress disorder in patients with mild traumatic brain injury. The correc...
KEY FINDING: The primary finding is a correction of the material measured; GFAP was measured in plasma, not serum, in the original study.