Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 291-300 of 639 results
The Journal of Spinal Cord Medicine, 2020 • July 1, 2020
This study investigated the safety of fenofibrate therapy in persons with SCI to determine the safety profile of 4 months of once-daily fenofibrate treatment when initiated using modified intervention...
KEY FINDING: Four out of 15 participants experienced an adverse event, including gastrointestinal distress and elevated liver enzymes, leading to three subjects discontinuing the medication.
Physiological Reports, 2019 • October 1, 2019
This study compared the effects of abaloparatide and teriparatide on bone structure, turnover, and signaling pathways in mice and cells. The results showed that abaloparatide had a greater osteoanabol...
KEY FINDING: Abaloparatide caused a greater dose-dependent increase in cortical thickness than teriparatide.
Spinal Cord Series and Cases, 2019 • September 1, 2019
This randomized, double-blinded, placebo-controlled, crossover study explored the effectiveness of botulinum toxin A (BoNTA) for treating at-level spinal cord injury (SCI) pain. Although the data did ...
KEY FINDING: A higher proportion of participants reported a marked change in average pain intensity from baseline to 8 and 12 weeks post-BoNTA vs. post-placebo (33% vs. 0%).
Journal of International Medical Research, 2019 • April 1, 2019
The study aimed to determine the role of spinal adenosine A1 receptors (A1Rs) in the analgesic effects of electroacupuncture (EA) for neuropathic pain using a rat model. Results showed that EA increas...
KEY FINDING: Electroacupuncture (EA) at the zusanli acupoint increases adenosine levels in the L4–6 spinal cord of rats.
BMC Neurology, 2020 • January 20, 2020
The study examined healthcare providers' experiences with medication therapy management (MTM) for individuals with spinal cord injury/dysfunction (SCI/D). Participants discussed their experiences and ...
KEY FINDING: Healthcare providers generally felt that caring for SCI/D patients was similar to caring for other patients, but with added complexity due to physical limitations. Most participants felt that the care they provided for persons with SCI/D was similar to the care that they provided to other patients, with some differences relating to the physical limitations and medical complexity associated with SCI/D.
Nutrients, 2020 • January 3, 2020
The study investigates the antinociceptive and anti-inflammatory effects of Nypa fruticans Wurmb extracts (NFE) in a rat model of sciatic nerve crush injury, focusing on the role of TRPV1. Results ind...
KEY FINDING: NFE (500 mg/kg) significantly delayed paw withdraw reaction in thermal hyperalgesia test compared to the vehicle group.
INTERNATIONAL JOURNAL OF MOlecular medicine, 2020 • January 31, 2020
The study aimed to evaluate the effect of the CX3CR1 inhibitor AZD8797 in early recovery after acute SCI and elucidate its potential mechanism in blocking inflammation and apoptosis. AZD8797 improved ...
KEY FINDING: CX3CR1 and CX3CL1 expression levels increase after spinal cord injury, peaking at 10 days, suggesting their involvement in the inflammatory response.
Spinal Cord Series and Cases, 2020 • March 27, 2020
This case report presents a 19-year-old male who developed a spinal cord injury after using ecstasy. The patient presented with rapidly progressive loss of motor function and dysesthesia in both lower...
KEY FINDING: A 19-year-old male developed a T11 AIS B SCI/D (spinal cord injury/dysfunction) following recreational use of ecstasy.
J Cell Mol Med, 2020 • August 1, 2020
This study assesses the neuroprotective effects of sitagliptin and explores the possible underlying molecular mechanism of the neuroprotection of sitagliptin after SCI both in vivo and in vitro. It wa...
KEY FINDING: Sitagliptin administration significantly increased GLP-1R protein level, alleviated neuronal apoptosis following SCI. Administration of sitagliptin significantly increased GLP-1R protein level, alleviated neuronal apoptosis
Spinal Cord Series and Cases, 2020 • July 29, 2020
This study explores the use of topical analgesics for treating neuropathic pain (NP) in spinal cord injury (SCI) through a literature review and patient interviews. The findings suggest that topical a...
KEY FINDING: The literature review identified seven studies (five case reports and two case series) that evaluated topical analgesics for SCI-related NP, with all reporting a decrease in NP over time.