Pharmacology Research

KEY FINDING: Muscle loss after SCI is more rapid than in other disuse conditions, with distinct molecular signaling cascades.

KEY FINDING: Both baclofen plus physical therapy and tolperisone plus physical therapy significantly improved muscle tone and strength compared to physical therapy alone.

KEY FINDING: Neuropathic pain after SCI involves complex mechanisms including neuronal excitability, glial dysregulation, and chronic inflammation.

KEY FINDING: Both CX717 and CX1739 increased diaphragm EMG output ipsilateral to C2Hx during both baseline breathing and acute respiratory challenge at 4 days post-injury.

KEY FINDING: Lap/MS@Mel hydrogels continuously released melatonin for at least 28 days in vitro, showing a more stable sustained release and better neural recovery ability in SCI rats.

KEY FINDING: A single low-energy shockwave pulse can noninvasively and selectively open the BCSFB.

KEY FINDING: The combined treatment with MP and FLX significantly decreased the expression levels of TNF-α and IL-6 in rats with SCI and hypothyroidism.

KEY FINDING: CBG pre-treatment mitigates apoptosis signaling and manages oxidative stress in injured cells.

KEY FINDING: Medical gases like carbon monoxide (CO) and xenon (Xe) show promise in protecting tissues and improving function, particularly in the central nervous system (CNS), heart, retina, liver, kidneys, and lungs.

KEY FINDING: 5-HT1A receptor agonists have shown positive changes in locomotor function in animal models of SCI or in humans.