Simultaneous Administration of Hyperbaric Oxygen Therapy and Antioxidant Supplementation with Filipendula ulmaria Extract in the Treatment of Thermal Skin Injuries Alters Nociceptive Signalling and Wound Healing

Medicina, 2023 · DOI: 10.3390/medicina59091676 · Published: September 17, 2023

Pharmacology Nutrition & Dietetics Dermatology

Simple Explanation

Thermal skin injuries are a significant cause of skin damage, leading to potential morbidity and mortality. This study explores the effects of hyperbaric oxygen treatment (HBO) and antioxidant supplementation with Filipendula ulmaria extract on thermal skin injuries. The research used rats with thermal injuries, treated with HBO and Filipendula ulmaria extract. The study assessed the macroscopic and histopathological characteristics, gene expression of pro-inflammatory mediators, opioid receptors, and behavioral testing for pain. The study concludes that the simultaneous use of HBO and antioxidant supplementation shows advantages in treating thermal skin injuries, specifically in reducing pain sensations associated with such trauma.

Study Duration

7 days

Participants

42 two-month-old male Wistar albino rats

Evidence Level

Not specified

Key Findings

1
Simultaneous administration of hyperbaric oxygen therapy and antioxidant supplementation with Filipendula ulmaria extract significantly ameliorated the macroscopic and histopathological characteristics of the wound area and healing.
2
The therapeutic approach decreased the local expression of genes for proinﬂammatory mediators and increased the expression of the µ-opioid receptor and the MT1 and MT2 receptors in the wound area and spinal cord.
3
Combined treatment with FU extract and HBO resulted in a signiﬁcant prolongation of reaction time compared to the burns and HBO-alone groups in behavioral testing.

Research Summary

This study investigates the effects of hyperbaric oxygen therapy (HBO) and antioxidant supplementation with Filipendula ulmaria extract, individually and simultaneously, in treating thermal skin injuries in rats. The results indicate that combined HBO and antioxidant supplementation significantly improved wound healing, reduced inflammation, increased the expression of opioid and melatonin receptors, and attenuated pain sensations. The study concludes that the simultaneous use of HBO and antioxidant supplementation provides advantages in treating thermal skin injuries, particularly in reducing pain. Further research is recommended to understand the additive mechanisms.

Practical Implications

Improved Wound Healing

Combined HBO and antioxidant supplementation can enhance wound closure and tissue regeneration in thermal skin injuries.

Pain Management

The combined therapy shows potential for reducing pain and nociceptive signaling associated with thermal burns.

Clinical Application

The findings suggest a promising therapeutic approach for managing burn injuries by integrating HBO and natural antioxidant supplements.

Study Limitations

1
The study was conducted on rats, and results may not directly translate to humans.
2
The study did not measure the parameters of oxidative stress in the area of the burn injury.
3
Further research is needed to explain the additive and mutual mechanisms of action of HBO and antioxidant supplementation.

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