Role of CD36 in central nervous system diseases

CD36, a protein found in the nervous system, is involved in processes that worsen central nervous system diseases like stroke and Alzheimer's. Targeting CD36 with antagonists could provide new treatment strategies. CD36 dysregulation is related to Parkinson’s disease (PD), stroke, Alzheimer’s disease (AD), and other neurological diseases. CD36 is involved in mediating endothelial dysfunction, oxidative stress, mitochondrial dysfunction, and inflammatory responses, which can accelerate neurodegenerative processes and cognitive decline. The review explores the mechanisms of action of CD36 antagonists, such as Salvianolic acid B, tanshinone IIA, curcumin, sulfosuccinimidyl oleate, antioxidants, and small-molecule compounds. Moreover, the structures of binding sites between CD36 and antagonists were predicted.

• 1
  CD36 mediates endothelial dysfunction, oxidative stress, mitochondrial dysfunction, and inflammatory responses, contributing to CNS diseases.
• 2
  CD36 antagonists like Salvianolic acid B, tanshinone IIA, and curcumin show promise in inhibiting CD36-mediated pathways.
• 3
  Molecular docking predictions suggest specific binding sites between CD36 and antagonists, offering targets for drug development.