Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 181-190 of 639 results
J Control Release, 2023 • December 1, 2023
This study explored nanoparticles containing antioxidant enzymes (antioxidant NPs) to neutralize excess ROS at the lesion site and its impact. Overall data suggest that restoring the redox balance a...
KEY FINDING: a single dose of antioxidant NPs, administered intravenously three hours after injury, effectively restored the redox balance at the lesion site, interrupting the secondary injury progression.
International Journal of Spine Surgery, 2023 • October 26, 2023
This study aimed to investigate the effect of methylprednisolone (MP) intrathecal injection on a rat model of acute spinal cord injury (ASCI). The results showed that MP intrathecal injection after AS...
KEY FINDING: Grb2 expression was downregulated in the MP groups compared to the control groups at various time points after injury.
Journal of Translational Medicine, 2023 • November 15, 2023
This study demonstrates that orally administered LbGp can improve the inflammatory microenvironment in SCI and promote spinal cord repair by inhibiting the MAPK-NF-κB/pyroptosis-related pathways. LbGp...
KEY FINDING: LbGp treatment could improve the motor function of rats after SCI, with the BBB motor function score of the LbGp intervention group being higher than that of the SCI group on day 14.
J South Med Univ, 2023 • October 1, 2023
This study investigated the therapeutic effect of metformin on pathological pain in mice with radiation dermatitis and explored the underlying mechanism. The results showed that metformin can signific...
KEY FINDING: Metformin alleviated radiation dermatitis symptoms in mice compared to the model group and a positive control group (Gabapentin).
Cureus, 2023 • October 11, 2023
The utilization of BTX-A in the treatment of various forms of neuralgia and neuropathic pain shows promising outcomes in terms of reducing pain and improving overall patient outcomes. BTX-A's mechanis...
KEY FINDING: BTX-A has demonstrated effectiveness in treating various conditions, including postherpetic neuralgia (PHN), auriculotemporal neuralgia (ATN), occipital neuralgia (ON), leprosy-induced neuropathic pain (LIN).
Clin Transl Sci, 2024 • January 1, 2024
This study explored the pharmacokinetics (PK) and pharmacodynamics (PD) of THC and CBD in MS patients. The concentrations of orally administered THC and CBD were low, necessitating a reanalysis with h...
KEY FINDING: The variation in daily dose and PK between individuals was considerable in a steady state, yet comparable with previous reports from healthy controls.
Scientific Reports, 2023 • November 2, 2023
The results of this study showed that resveratrol treatment can promote the recovery of SCI in rat contusion models by inhibiting the activation of the JNK/p38MAPK signaling pathway. Resveratrol treat...
KEY FINDING: Resveratrol dramatically improved the hindlimb locomotor function and their electrophysiological outcomes.
Pharmaceuticals, 2023 • November 18, 2023
This study investigated the effect of URB937, a blood–brain barrier impermeant FAAH inhibitor, on experimentally induced mechanical allodynia in an animal model of trigeminal neuralgia. URB937 treatme...
KEY FINDING: URB937 treatment prevented the development of mechanical allodynia in rats subjected to chronic constriction injury of the infraorbital nerve (IoN-CCI).
Ulus Travma Acil Cerrahi Derg, 2023 • December 1, 2023
This study investigates the potential of Shilajit to mitigate secondary damage in spinal cord injury (SCI) using a rat model. Rats were divided into control, low-dose Shilajit, and high-dose Shilajit ...
KEY FINDING: Histopathological examination showed that the high-dose Shilajit group had lower amounts of morphological damage compared to the low-dose and control groups.
Journal of Neuroinflammation, 2023 • December 4, 2023
This study evaluated the effects of hyperbaric oxygen (HBO) and normobaric oxygen therapy on neuroinflammation and respiratory recovery in a rat model of spinal cord injury (SCI). The key finding was ...
KEY FINDING: Both hyperbaric and normobaric oxygen therapy significantly reduced the inflammatory response in the injured spinal cord, as evidenced by transcriptomic analysis and immunohistochemical markers for astrocytes and microglia.