Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 81-90 of 682 results
Neurobiology of Pain, 2022 • October 12, 2022
This study investigates sex-specific differences in spinal cord microglial activation and myeloid cell infiltration following peripheral injury using a mouse model of complex regional pain syndrome (C...
KEY FINDING: Spinal cord microglial activation is attenuated and delayed in females compared to males after peripheral injury.
Korean J Pain, 2023 • January 1, 2023
This study demonstrated the mechanism of HNSC-secretome in improving neuropathic pain and locomotor function in SCI through antioxidant, anti-inflammatory, anti-matrix degradation, and neurotrophic ac...
KEY FINDING: HNSC-secretome treatment significantly decreased F2-Isoprostane levels, indicating antioxidant activity.
Cells, 2022 • December 14, 2022
The study demonstrates that cutaneous injection of resiniferatoxin (RTX) can completely alleviate and prevent nerve-injury-induced neuropathic pain in rats. RTX treatment resulted in the downregulatio...
KEY FINDING: Intraplantar injection of RTX completely reversed the development of chronic thermal and mechanical hypersensitivity in rats with nerve injury.
Cells, 2022 • December 19, 2022
The study investigated the expression and distribution of 2-AG in the brain and spinal cord of a spare nerve injury (SNI) mice model of neuropathic pain using DESI-MSI. The results showed that 2-AG ex...
KEY FINDING: On days 3 and 7 after SNI treatment, 2-AG expression decreased in the hypothalamus, midbrain, and especially in the periaqueductal gray (PAG) region.
Int. J. Mol. Sci., 2022 • December 14, 2022
This study demonstrates that loganin, an iridoid glycoside, can modulate autophagic flux in a rat model of chronic constriction injury (CCI)-induced neuropathic pain. The results indicate that loganin...
KEY FINDING: Loganin attenuated the expression of Beclin-1, LC3B-II, and p62 in CCI rats, suggesting an improvement in autophagic flux.
Journal of Pain Research, 2022 • December 16, 2022
This retrospective study evaluated the clinical outcomes of amniotic membrane/umbilical cord (AMUC) particulate injections in patients with musculoskeletal spinal disorders. The study found that AMUC ...
KEY FINDING: AMUC injections significantly reduced pain in patients with spinal disorders, with pain scores decreasing as early as two weeks post-injection.
Brain and Behavior, 2023 • January 1, 2023
Neuropathic pain (NP) involves abnormal sensory signals across the nervous system, leading to significant pain. Neuron-glial cell interaction is related to the pathogenesis of NP, with activation of m...
KEY FINDING: The microglia P2X4 receptor plays a central role in neuropathic pain, activating pathways that affect both astrocytes and neurons.
Cells, 2023 • December 26, 2022
This study comprehensively investigates the roles of CCR1, CCR3, and their endogenous ligands in neuropathic pain using a murine model of chronic constriction injury (CCI). The research identifies tim...
KEY FINDING: CCL2/7/8 protein levels were significantly increased in the spinal cord following chronic constriction injury (CCI) of the sciatic nerve, suggesting their involvement in both the development and maintenance of neuropathic pain.
Frontiers in Immunology, 2022 • December 22, 2022
The study investigates the role of the XCL1 chemokine and its receptors, XCR1 and ITGA9, in neuropathic pain using a chronic constriction injury (CCI) model in mice. Key findings include the upregulat...
KEY FINDING: XCL1 expression increases in the spinal cord after nerve injury and is mainly produced by astroglial cells.
Neurosci. Bull., 2023 • January 13, 2023
The study elucidated the role of exon-intron circRNA, circFhit, as a critical regulator in the pathogenesis of neuropathic pain induced by peripheral nerve injury. CircFhit modulation of FHIT expressi...
KEY FINDING: CircFhit, an exon-intron circRNA, is upregulated in the spinal dorsal horn in a neuropathic pain model and contributes to neuropathic pain following spared nerve injury (SNI).