Pain Management Research

KEY FINDING: IB4+ sensory neurons are selectively involved in inflammation- and tissue injury–induced mechanical pain hypersensitivity, but not in neuropathic pain.

KEY FINDING: The synthesized CONPs were 6.8 ± 0.5 nm in size, presenting a cubic morphology.

KEY FINDING: Spared nerve injury (SNI) enhances the excitability of Y1-INs and elicits allodynia and affective pain.

KEY FINDING: Veratramine significantly increased the mechanical withdrawal threshold in DPN rats, indicating reduced pain sensitivity.

KEY FINDING: The patient developed posterior cord syndrome, specifically a loss of proprioception, immediately after the insertion of a paddle-type SCS electrode lead.

KEY FINDING: Intravenous administration of HUC-MSCs significantly ameliorated CCI-induced mechanical allodynia and thermal hyperalgesia in rats.

KEY FINDING: GSK189254 reversed mechanical and thermal allodynia in SNI mice, but this effect was prevented by blocking H4R with JNJ 10191584.

KEY FINDING: Intrathecal NIS-lncRNA antisense oligonucleotides attenuated CCI-induced mechanical allodynia, heat hyperalgesia, cold hyperalgesia, and ongoing nociceptive responses, without changing basal or acute nociceptive responses and locomotor function.

KEY FINDING: Clec7a is significantly upregulated in spinal cord tissues of rats with chronic constriction injury (CCI), a model for neuropathic pain.

KEY FINDING: Spared nerve injury (SNI) led to mechanical and cold allodynia, elevated expression of latency-associated peptide- (LAP-) TGF-β1, and activated astroglial in the spinal cord.