Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 91-100 of 682 results
Ann Transl Med, 2022 • December 1, 2022
In ipsilateral L4-L6 DRGs, SNI-induced activation of macrophages was accompanied by reduced autophagy. EA alleviated SNI-induced NP and activated the autophagy process in DRG macrophages. These result...
KEY FINDING: SNI achieved a significant upregulation of autophagy levels in DRG macrophages.
J Clin Invest, 2023 • March 1, 2023
Microglia, resident macrophages of the CNS, are essential to brain development, homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS diseases, including neuropat...
KEY FINDING: TRPV4 is functionally expressed in spinal resident microglia and its expression is increased in a mouse model of spared nerve injury (SNI).
Pain, 2023 • July 1, 2023
The study identifies the VEGF-A/NRP1 interaction as a potential target for pain relief. Blocking this interaction with the compound NRP1-4 decreases sensory neuron excitability. NRP1-4 reduces pain-re...
KEY FINDING: NRP1–4 blocks the increase in excitability of sensory neurons caused by VEGF-A, suggesting it interferes with VEGF-A's action on these neurons.
Molecular Pain, 2023 • January 25, 2023
This study investigated the effects of Resolvin D1 (RvD1) on mechanical allodynia after burn injury in rats. The researchers found that RvD1 attenuated mechanical allodynia, prevented glial activation...
KEY FINDING: RvD1 attenuates mechanical allodynia after burn injury in rats.
Journal of Neuroinflammation, 2023 • February 3, 2023
This study investigates the potential of inducible co-stimulatory molecule (ICOS) in resolving CIPN pain-like behaviors in mice, finding that ICOS agonist antibody (ICOSaa) alleviates mechanical hyper...
KEY FINDING: ICOS agonist antibody (ICOSaa) promotes paclitaxel-evoked pain resolution in female mice.
bioRxiv preprint, 2023 • January 30, 2023
This study established a rat in vivo model of EP microfracture that caused MC type 1-like changes, IVD degeneration, and spinal cord sensitization. The presence of the EP microfracture injury caused c...
KEY FINDING: EP microfracture induced IVD degeneration and height loss, Modic-like changes, and increased pain-like behaviors with spinal cord sensitization.
Pain Research and Management, 2023 • February 8, 2023
This study investigates the potential of sEH inhibition, using TPPU, as a therapeutic target for paclitaxel-induced peripheral neuropathy (PIPN) in rats. The research aims to determine if TPPU can all...
KEY FINDING: TPPU restored mechanical and thermal thresholds in rats treated with nab-paclitaxel, indicating pain relief.
Int. J. Mol. Sci., 2023 • February 8, 2023
The study investigated the effects of endplate (EP) injuries on spinal cord sensitization and neuroinflammation in rats with intervertebral disc degeneration. Results showed that EP injuries led to in...
KEY FINDING: EP injuries significantly increased SubP, Iba1, and GFAP in the dorsal horn of the spinal cord, indicating spinal cord sensitization and neuroinflammation.
Nat Neurosci, 2023 • April 1, 2023
The study identifies catecholaminergic neurons in the caudal ventrolateral medulla (cVLM) that are activated by noxious stimuli and produce bilateral feed-forward inhibition that attenuates nociceptiv...
KEY FINDING: Catecholaminergic neurons in the caudal ventrolateral medulla (cVLM) are activated by noxious stimuli.
PLoS ONE, 2023 • March 13, 2023
This study evaluated the analgesic potential of CBD and BCP individually and in combination in a rat spinal cord injury (SCI) clip compression chronic pain model. Individually, both phytocannabinoids ...
KEY FINDING: Both CBD and BCP individually reduced tactile and cold hypersensitivity in male and female rats with SCI in a dose-dependent manner.