Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 61-70 of 682 results
Journal of Pain Research, 2022 • September 13, 2022
This study investigates the effects of differential target multiplexed spinal cord stimulation (DTMP) and traditional low-rate spinal cord stimulation (LR-SCS) on the mTOR pathway in a neuropathic pai...
KEY FINDING: DTMP and LR-SCS reverse injury-induced changes of the mTOR pathway while treating neuropathic pain.
Medicina, 2022 • September 7, 2022
This case report describes a spinal cord injury following cervical interlaminar epidural steroid injection (CIESI) in a 35-year-old woman, highlighting potential risks and complications associated wit...
KEY FINDING: Fluoroscopy does not guarantee the prevention of spinal cord penetration during CIESI procedures.
BMC Neurology, 2022 • January 1, 2022
This study investigates the role of DNMT1 in neuropathic pain (NP) and explores the potential of RNA interference-mediated DNMT1 silencing to alleviate CCI-induced NP in rats. The study demonstrates t...
KEY FINDING: DNMT1 was upregulated in microglia of CCI rats, suggesting its involvement in neuropathic pain.
Neurospine, 2022 • September 1, 2022
Traumatic spinal cord injury (SCI) leads to secondary complications like chronic neuropathic pain (CNP) and spasticity, significantly affecting patients' daily lives. The mechanisms behind CNP post-SC...
KEY FINDING: Excitotoxicity mediated GABAergic cell loss, downregulation of glutamate acid decarboxylase enzyme, upregulation of gamma-aminobutyric acid (GABA) transporters, overactivation of glutamate receptors are some of the key evidence for hypoactive inhibitory tone contributing to CNP and spasticity post-SCI.
Journal of Neuroinflammation, 2022 • October 4, 2022
This study investigates the effect of SAFit2 on nerve injury-induced neuropathic pain in mice. The findings indicate that SAFit2 reduces neuroinflammation and ameliorates mechanical hypersensitivity. ...
KEY FINDING: SAFit2 ameliorates nerve injury-induced neuropathic pain by reducing neuroinflammation.
Neuron, 2022 • December 21, 2022
This study demonstrates that spared nerve injury (SNI) leads to mechanical hypersensitivity and neuropathic pain by triggering homeostatic reduction of inhibitory outputs from dorsal horn parvalbumin-...
KEY FINDING: Spared nerve injury (SNI) induces mechanical hypersensitivity and neuropathic pain through homeostatic reduction of inhibitory outputs from dorsal horn parvalbumin-positive (PV+) interneurons.
Frontiers in Cellular Neuroscience, 2022 • September 26, 2022
The study investigates the role of TrkB signaling in pain and locomotor dysfunction following spinal cord injury (SCI) in mice using pharmacogenetic inhibition. Results indicate that early TrkB inhibi...
KEY FINDING: Inhibition of TrkB signaling after SCI attenuates the onset and maintenance of mechanical hypersensitivity after SCI.
Int. J. Mol. Sci., 2022 • September 24, 2022
This study investigates the role of AhR in neuropathic pain using nerve explant cultures and a CCI model in mice. The findings suggest that AhR agonists could be potential candidates for neuropathic p...
KEY FINDING: Deletion of AhR aggravated nerve damages and this was restored by omeprazole, indicating a protective role of AhR in nerve health.
Neurochemical Research, 2022 • October 26, 2022
The study aimed to investigate the effects of linalyl acetate (LA) on neuropathic pain caused by sciatic nerve injury (SNI) in rats, focusing on the TSLP and IL-33 signaling pathways. The results show...
KEY FINDING: LA attenuated mechanical hyperalgesia in SNI rats, indicating a reduction in pain sensitivity.
Frontiers in Immunology, 2022 • October 13, 2022
This study investigates the role of IRG1/itaconate in neuropathic pain, demonstrating that endogenous itaconate levels increase in the spinal cord following nerve injury. Deficiency of IRG1 exacerbate...
KEY FINDING: The levels of itaconate and IRG1 in the spinal cord significantly increased after CCI (chronic constriction nerve injury).