Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 651-660 of 682 results
NEUROGENESIS, 2016 • November 1, 2016
Adult spinal cord neurogenesis is a process where new neurons are generated in the spinal cord, influencing pain sensitivity. Under normal conditions, it helps maintain a stable level of pain sensitiv...
KEY FINDING: Adult spinal cord neurogenesis contributes to maintaining a steady-state level of nociceptive sensitivity under normal conditions.
Neural Regeneration Research, 2017 • March 1, 2017
The study aimed to determine whether a relationship exists between estrogen and NMDAR1 in peripheral nerve pain using a rat model of chronic sciatic nerve constriction injury. Rats administered estrad...
KEY FINDING: Estrogen administration significantly reduced mechanical and thermal pain thresholds in rats with chronic constriction of the sciatic nerve.
Scientific Reports, 2017 • August 17, 2017
This study investigates the therapeutic potential of human anti-RGMa antibodies in treating spinal cord injury (SCI) by promoting regeneration and reducing neuropathic pain. The research demonstrates ...
KEY FINDING: RGMa is significantly upregulated in multiple cell types following impact-compression SCI in rats and in the injured human spinal cord.
Data in Brief, 2017 • October 7, 2017
This data article presents findings on the expression patterns of leptin (Lep) and its receptor (LepR) in the dorsal root ganglion (DRG) and spinal cord following preganglionic cervical root avulsion ...
KEY FINDING: Generalized expression of Lep and LepR was noted 7 days after PCRA in DRG neurons.
Frontiers in Pharmacology, 2017 • October 17, 2017
This work demonstrates the effect of combined long-chain omega-3 fatty acids (CFO), EPA and DHA, in nerve regeneration and prevention of NP in mice, shedding light on its mechanism of action. Our resul...
KEY FINDING: CFO at 2.3 g/kg significantly prevented mechanical allodynia and reduced thermal hypernociception in mice compared to animals receiving vehicle only.
Toxins, 2018 • March 18, 2018
This study aimed to verify if BoNT/B is able to counteract neuropathic pain, and to interfere with inflammatory and regenerative processes associated with nerve injury. The results of this study show ...
KEY FINDING: BoNT/B reduces neuropathic pain over a long period of time, similar to BoNT/A.
Molecular Pain, 2018 • April 10, 2018
This study investigated the effects of blocking TRPV1 with AMG-517 on nerve regeneration after sciatic nerve injury in rats. The results showed that AMG-517 promoted axonal regeneration, decreased gli...
KEY FINDING: Blockage of TRPV1 with AMG-517 markedly promoted axonal regeneration, especially at two weeks after sciatic injury.
Medical Devices: Evidence and Research, 2018 • January 1, 2018
The study introduces a novel electroceutical device that delivers percutaneous direct current (DC) stimulation to treat severe neurological pain and soft tissue injuries. The device mimics and modulat...
KEY FINDING: Percutaneous DC stimulation significantly reduced pain and attack frequency in a patient with chronic cluster headaches, leading to complete remission for over 3 years.
British Journal of Pharmacology, 2018 • January 1, 2018
This study investigates the analgesic effects of ASP3662, a novel 11β-HSD1 inhibitor, in rat models of neuropathic and dysfunctional pain. ASP3662 is a potent, selective, and CNS-penetrable inhibitor ...
KEY FINDING: ASP3662 effectively inhibits 11β-HSD1 in humans, mice, and rats, demonstrating selectivity over 11β-HSD2 and showing no significant impact on other enzymes, transporters, and receptors.
Neural Regen Res, 2018 • June 1, 2018
This study investigates the analgesic effect of AG490 on oxaliplatin-induced acute neuropathic pain in rats. The findings demonstrate that AG490 attenuates oxaliplatin-induced acute neuropathic pain b...
KEY FINDING: AG490 treatment significantly increased paw withdrawal threshold and tail withdrawal latency in rats with oxaliplatin-induced neuropathic pain, indicating reduced sensitivity to mechanical and cold stimuli.