Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 661-670 of 682 results
PNAS, 2018 • August 20, 2018
The study reveals that advillin, a sensory neuron-specific protein, plays a critical role in axonal regeneration of IB4+ sensory neurons and facilitates recovery from peripheral neuropathy and neuropa...
KEY FINDING: Advillin expression is restricted to isolectin B4-positive (IB4+) neurons in the adult dorsal root ganglia (DRG).
Frontiers in Bioengineering and Biotechnology, 2020 • February 19, 2020
This study aimed to identify key genes and cellular components involved in SCI-related neuropathic pain using transcriptome bioinformatics analysis. The analysis revealed that HAVCR2, a receptor on NK...
KEY FINDING: Identified 2,314 genes as differentially expressed between SCI patients and healthy controls.
Cells, 2020 • March 27, 2020
The study investigates the effect of NeuroHeal, a combination of Acamprosate and Ribavirin, on sensory fiber regeneration and neuropathic pain in rat models of peripheral nerve injury. The treatment a...
KEY FINDING: NeuroHeal treatment reduced signs of neuropathic pain in rat models of spare nerve injury and nerve crush.
International Journal of Molecular Sciences, 2020 • May 15, 2020
The study demonstrated that the association of PEAum and Paracetamol, in a low dose (5 mg/kg + 30 mg/kg), reduced hyperalgesia, mast cell activation, c-Fos and nerve growth factor (NGF) expression, ne...
KEY FINDING: PEAum–Paracetamol association reduced hyperalgesia, mast cell activation, c-Fos and nerve growth factor (NGF) expression, neural histological damage, cytokine release, and apoptosis in a rat model of sciatic nerve injury (SNI).
Cureus, 2020 • October 27, 2020
ESWT shows promise in increasing bone mineral density in osteoporosis patients and reducing pain associated with heterotopic ossification after spinal cord injury. ESWT can improve range of motion and...
KEY FINDING: ESWT may increase bone mineral density (BMD) in patients with osteoporosis, potentially prolonging the asymptomatic period of vertebral body compressive changes and radicular symptoms.
Scientific Reports, 2021 • January 11, 2021
This study aimed to assess whether UPAL gel implantation reduces inflammatory cytokine levels, prevents intervertebral disc degeneration, and reduces acute pain after discectomy in rat and rabbit disc...
KEY FINDING: UPAL gel implantation suppressed TNF-α and IL-6 production in both rat and rabbit models of discectomy.
iScience, 2021 • February 19, 2021
This study provides in vivo evidence showing that repeated EA treatment modulates the cortical circuit to relieve neuropathic pain. The activation of CB1R by EA leads to presynaptic inhibition at GABA...
KEY FINDING: EA treatment reduces both mechanical and thermal hypersensitivity in mice with neuropathic pain, indicating its analgesic effects.
PNAS, 2001 • July 3, 2001
The study investigates the roles of BDNF and NT-4 in spinal cord sensory processing using knockout mice and an in vitro spinal cord preparation. Results show that BDNF, but not NT-4, is necessary for ...
KEY FINDING: BDNF-deficient mice showed reduced ventral root potential (VRP) evoked by stimulating nociceptive primary afferents, indicating impaired nociceptive transmission.
The Journal of Neuroscience, 2004 • May 19, 2004
This study demonstrates that peripheral nerve injury leads to an increased expression of the Nav1.3 sodium channel in second-order spinal sensory neurons. The upregulation of Nav1.3 contributes to the...
KEY FINDING: Peripheral nerve injury upregulates the expression of Nav1.3 in dorsal horn nociceptive neurons, but not in astrocytes or microglia.
PNAS, 2006 • January 17, 2006
This study demonstrates the role of Cdk5 in nociceptive signaling. It identifies the expression of Cdk5 and its activator p35 in nociceptive neurons and shows that this expression is modulated during ...
KEY FINDING: Cdk5 and p35 are expressed in pain-sensing neurons (nociceptors) within the dorsal root ganglia (DRG), trigeminal ganglia (TG), and spinal cord (SC).