Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 571-580 of 682 results
Pain Research and Management, 2019 • April 28, 2019
The study aimed to clarify the mechanisms underlying pain reduction by PRF treatment on DRG, focusing on the levels of BDNF, PI3K, and p-ERK in the spinal cord of rats with spared nerve injury (SNI). ...
KEY FINDING: SNI induced a long-lasting increase in microglia hyperactivity and BDNF, PI3K, and p-ERK upregulation in the spinal cord and resulted in pain sensitization.
Spinal Cord Series and Cases, 2019 • March 17, 2019
This study used International SCI Data Sets to assess pain and quality of life (QoL) in adults with chronic SCI. The study found a high prevalence of complex and persistent pain symptoms in individual...
KEY FINDING: Most participants with SCI reported having multiple types and locations of pain, despite receiving treatment for pain.
GMS German Medical Science, 2019 • June 17, 2019
This clinical practice guideline provides a structured approach to pain management in individuals with spinal cord injury (SCI), addressing challenges in classification, assessment, and therapy. The g...
KEY FINDING: The guideline recommends the International Spinal Cord Injury Pain (ISCIP) classification for SCI-related pain.
BMC Neuroscience, 2019 • July 23, 2019
This study investigated whether post-surgical inhibition of PI3K could alleviate postoperative pain (POP) and the underlying mechanisms in mice subjected to plantar incision. The results demonstrated ...
KEY FINDING: Post-surgical inhibition of PI3K significantly reduced mechanical allodynia, thermal hyperalgesia, and cumulative pain scores in male mice after plantar incision.
Frontiers in Neuroscience, 2019 • July 25, 2019
This study investigated the feasibility of self-managed neurofeedback (NFB) treatment for central neuropathic pain (CNP) in individuals with chronic spinal cord injury (SCI). The results showed that a...
KEY FINDING: Twelve participants achieved statistically significant reduction in pain, and in eight participants this reduction was clinically significant (larger than 30%).
Spinal Cord Series and Cases, 2019 • April 23, 2019
This international survey of physicians reveals that opioid prescribing practices for chronic pain in persons with spinal cord damage (SCD) often differ from established clinical practice guidelines. ...
KEY FINDING: Most physicians prescribe opioids for intractable pain after SCD, but a significant proportion do not believe in a specific upper limit of opioid dose if the drug is tolerated.
Spinal Cord Series and Cases, 2019 • June 26, 2019
This study explored the utilization of medicinal cannabis (MC) among individuals with spinal cord injury (SCI) to manage pain and other symptoms. The research compared current, past, and never users o...
KEY FINDING: Current and past MC users reported greater pain interference in daily life compared to never users.
Spine Surg Relat Res, 2019 • January 1, 2019
This nationwide survey investigated spinal cord-related pain syndrome in Japan, focusing on neuropathic pain associated with spinal cord damage. The study identified common underlying conditions, the ...
KEY FINDING: The most frequent underlying conditions were cervical spondylotic myelopathy (26.7%), spinal cord injury (17.4%), and ossification of the posterior longitudinal ligament (OPLL) of the cervical spine (14.1%).
ANNALS OF NEUROSCIENCES, 2019 • April 1, 2019
This review aims to discuss the implications of various mechanistic approaches of yoga which can be tested by new study designs around various nociceptive molecules including matrix metalloproteinases...
KEY FINDING: Yoga may increase pain tolerance in SCI and other patients with pain. Various studies have noted improvement in sleep, mood, and quality of life (i.e. depression, emotional function, anxiety) among cancer patients.
CANADIAN JOURNAL OF PAIN/REVUE CANADIENNE DE LA DOULEUR, 2017 • January 1, 2017
A national Canadian summit was held to develop a strategic plan for improving neuropathic pain (NP) management after spinal cord injury (SCI). The summit identified strengths, such as evidence synthes...
KEY FINDING: Strengths in the field include rigorous evidence syntheses and practice landscape documentation, such as the CanPainSCI Clinical Practice Guidelines and the SCIRE website.