Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 41-50 of 682 results
Int. J. Mol. Sci., 2025 • March 13, 2025
This study aimed to elucidate the molecular mechanisms underlying the combined use of LGZ and SIN in treating NP using network pharmacology and metabolomics. The combination of LGZ and SIN demonstrate...
KEY FINDING: The combination of LGZ and SIN significantly alleviated pain-like behaviors in CCI rats in a time- and dose-dependent manner, demonstrating superior therapeutic effects compared to LGZ or SIN alone.
Neurochemical Research, 2025 • March 17, 2025
The study examined the protective effect of DEX on remifentanil-induced hyperalgesia in rats. Remifentanil, while effective for pain relief, can paradoxically increase pain sensitivity. The findings i...
KEY FINDING: DEX administration reduced mechanical allodynia and thermal hyperalgesia in rats experiencing remifentanil-induced hyperalgesia (RIH).
Bioelectronic Medicine, 2025 • March 6, 2025
The study investigated the effects of low-intensity trans-spinal focused ultrasound (tsFUS) on neuropathic pain in rats with chronic constriction injury (CCI). tsFUS was applied to the L5 spinal segme...
KEY FINDING: tsFUS treatment increased the von Frey threshold (vFT) in rats with CCI compared to sham treatment, indicating reduced mechanical sensitivity. This effect persisted for up to 23 days post-CCI.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
This clinical review assessed the use of Botulinum Toxin type A (BTX-A) for treating neuropathic pain in patients with spinal cord injuries, examining studies up to May 2020. The review found limited,...
KEY FINDING: There's limited research specifically on using BTX-A to treat neuropathic pain related to spinal cord injury, despite broader studies on other patient populations.
Neuromodulation, 2022 • October 1, 2022
The study evaluated the analgesic effects of burst DRG stimulation compared to tonic stimulation in a rat model of neuropathic pain. Results indicated that burst and tonic DRG stimulation had similar ...
KEY FINDING: All waveforms tested (20 Hz-tonic, 20 Hz-burst, and 40 Hz-burst) showed similar analgesic effects in sensory tests and conditioned place preference.
The Journal of Spinal Cord Medicine, 2024 • January 1, 2024
This study investigated the potential of tropisetron, an α7nAChR agonist, to alleviate neuropathic pain and neuroinflammation in rats with spared nerve injury (SNI). The results demonstrated that trop...
KEY FINDING: Tropisetron effectively alleviated mechanical allodynia and thermal hyperalgesia in rats with spared nerve injury (SNI).
Neurotherapeutics, 2022 • May 2, 2022
This study investigates the efficacy of dual HDAC/BRD4 inhibitors, SUM52 and SUM35, in treating neuropathic pain using a spared nerve injury (SNI) model in mice. The results indicate that both SUM52 a...
KEY FINDING: SUM52 and SUM35, administered intranasally, reduced thermal and mechanical hypersensitivity in mice with spared nerve injury (SNI), a model of neuropathic pain.
European Journal of Pain, 2022 • October 1, 2022
This study explored indicators of central sensitization in individuals with chronic neuropathic pain (NP) following spinal cord injury (SCI). Temporal summation of pain (TSP) and heat-induced sympathe...
KEY FINDING: Enhanced temporal summation of pain (TSP) was observed in SCI-NP (+66%) compared to SCI-nonNP (−75%, p = 0.009) and HC (−59%, p = 0.021).
Neurochemical Research, 2022 • July 16, 2022
This study investigates the role of TIPE2 in mitigating inflammation and neuropathic pain induced by sciatic nerve injury (SNI) in rats, focusing on the underlying mechanism involving TAK1. The experi...
KEY FINDING: TIPE2 exhibits a parabola-like change in expression in the spinal cord and DRG of SNI model rats over time.
Neural Regeneration Research, 2023 • February 1, 2023
This study investigated the role of ferroptosis in CFA-induced inflammatory pain in rats. The researchers found evidence of ferroptosis in the spinal cord and DRG tissues of these rats. Intrathecal a...
KEY FINDING: CFA-induced inflammatory pain in rats leads to ferroptosis in the spinal cord and dorsal root ganglion tissues.