Pain Management Research

KEY FINDING: Blocking KOR activation with norBNI prevented the negative effects of repeated intravenous morphine on locomotor recovery in rats with SCI.

KEY FINDING: Lumbar disc puncture in mice induces chronic hindpaw mechanical allodynia, hyperalgesia, grip weakness, and spontaneous pain, lasting up to 24 weeks.

KEY FINDING: α6-containing GABAA receptor blockade or knockdown induces hypersensitivity and spontaneous pain in naïve female rats.

KEY FINDING: The study found no significant difference in overall pain inhibition or pain amplification between individuals with spinal cord injury-related neuropathic pain and healthy controls when testing above the level of the lesion.

KEY FINDING: GSE and CE treatments modulated pain behaviors, reducing thermal hyperalgesia and mechanical allodynia in SCI mice.

KEY FINDING: A single intrathecal injection of sEVs durably reversed mechanical hypersensitivity in the left hind paw of mice with partial sciatic nerve ligation.

KEY FINDING: TSPO is upregulated with microglial activation during neuroinflammation, serving as a marker and predictor of chronic pain.

KEY FINDING: Exercise, including arm ergometry and treadmill training, shows promise in reducing SCI-induced pain and improving quality of life.

KEY FINDING: The patient experienced significant improvement in hand function and was able to maintain her normal physical routine for eight years following the second surgery (Vo-Vim thalamotomy).

KEY FINDING: Individuals with CRPS showed increased mechanical pain sensitivity compared to healthy controls in the affected area.