Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 391-400 of 452 results
Bioactive Materials, 2023 • January 1, 2023
This review provides an overview of the role of EVs in OA, focusing on the pathogenesis, diagnosis, and treatment, while considering the associated challenges and limitations. The review summarizes th...
KEY FINDING: EVs play a significant role in OA pathogenesis by influencing inflammation, metabolism, and cellular senescence within joint tissues.
Heliyon, 2022 • October 13, 2022
This study investigates the dynamics of cartilage-derived stem/progenitor cells (CSPCs) in osteoarthritis (OA) progression using single-cell transcriptomic data. The research reveals that CSPC heterog...
KEY FINDING: CSPCs exhibit significant heterogeneity that is closely associated with the progression of OA, indicating that the characteristics of CSPCs change during OA progression.
Trials, 2022 • November 3, 2022
This study protocol outlines a comprehensive cohort trial comparing full-endoscopic and microsurgical techniques for lumbar disc herniation treatment. The study includes a randomized and a non-randomi...
KEY FINDING: The study aims to compare the results of lumbar discectomies using the full-endoscopic technique via the interlaminar and trans-foraminal access with those of the conventional microsurgical technique, particularly with regard to iatrogenic muscle trauma and patient-related outcome measures.
Frontiers in Cell and Developmental Biology, 2022 • November 24, 2022
This study developed an icariin-loaded chitosan hydrogel (ICA/CTS) for cartilage regeneration, leveraging icariin's chondrogenic and anti-inflammatory properties. In vitro results demonstrated sustain...
KEY FINDING: The ICA/CTS hydrogel exhibited a favorable in vitro anti-inflammatory effect, suppressing inflammatory-related cytokines.
Frontiers in Bioengineering and Biotechnology, 2022 • December 16, 2022
This study found that HA treatment induces mitophagy in NPCs, preventing ROS overproduction and mitochondrial impairment, which subsequently inhibits cell apoptosis, senescence and ECM degradation via...
KEY FINDING: Hyaluronic acid (HA) can protect mitochondrial function through activation of mitophagy in nucleus pulposus cells (NPCs).
J. Clin. Med., 2023 • January 2, 2023
The study classified new bone formation in OPLL into plateau-shaped and hill-shaped patterns and investigated related factors, including serum hs-CRP levels and SI joint ankylosis. The research found ...
KEY FINDING: The plateau shape of OPLL was more common in vertebral segments, while the hill shape was predominant in intervertebral regions.
Medicina, 2023 • January 5, 2023
This study aimed to verify PRP injection safety and efficacy in LBP patients with Modic type 1. As a preliminary experiment, two LBP cases with Modic type 1 are presented. There were no adverse events ...
KEY FINDING: There were no adverse events in physical condition, laboratory data, or lumbar X-rays after injection, suggesting that PRP intradiscal injection is safe.
Int. J. Environ. Res. Public Health, 2023 • January 4, 2023
This retrospective study analyzed data from 159 CRPS patients to identify epidemiological and clinical factors associated with the condition. The study population consisted mainly of women with an ave...
KEY FINDING: The study confirmed a higher occurrence of CRPS in females. The hand and wrist were the most commonly affected areas, followed by the ankle and foot.
Int. J. Mol. Sci., 2023 • January 12, 2023
This study investigates the potential of using chondrocytes isolated from loose bodies (LB-CH) as a cell source for autologous chondrocyte implantation (ACI) to reduce donor site morbidity. LB-CH were...
KEY FINDING: LB-CH exhibited comparable viability and proliferation rates to control cells during long-term expansion, with no ultimate cell cycle arrest observed within 12 passages.
Cells, 2023 • February 3, 2023
This study explored the therapeutic potential of injecting a mixture of rapidly expanding clone (REC) cells and ultra-purified alginate (UPAL) non-gelling solution into intervertebral discs (IVDs) to ...
KEY FINDING: The injection of REC and UPAL mixture suppressed the expression of TNF-α, IL-6, and TrkA in rat models.