Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 401-410 of 452 results
World Journal of Orthopedics, 2023 • February 18, 2023
The study investigates the effects of human neural stem cells-secretome (HNSCs-secretome) on spinal cord injury (SCI) regeneration in a rat model. Results indicate that HNSCs-secretome improves locomo...
KEY FINDING: HNSCs-secretome significantly improved locomotor recovery, as measured by BBB scores, in rats with SCI.
BMC Musculoskeletal Disorders, 2023 • March 28, 2023
This study investigated the feasibility of minimally invasive plate osteosynthesis (MIPO) for treating distal humeral fractures, including both extra-articular and intra-articular types. The researche...
KEY FINDING: Reduction and plate fixation of all distal humeral fractures (8 cadaveric) with and without osteotomy was feasible.
JOR Spine, 2023 • April 1, 2023
This study investigates the role of DLX5 in the progression of OPLL, a condition characterized by the ossification of spinal ligaments. The findings indicate that DLX5 expression is upregulated in OPL...
KEY FINDING: DLX5 is highly expressed in OPLL cells compared to non-OPLL cells, both in vitro and in vivo.
Neurospine, 2023 • June 1, 2023
This study assessed the relationship between static and dynamic factors and the severity of cervical myelopathy in OPLL patients. The study found that minimal SAC, Cobb angle, total ROM, and local ROM...
KEY FINDING: Minimal space available for the spinal cord (SAC), C2–7 Cobb angle, total range of motion (ROM), and local ROM were identified as independent predictors of myelopathy in OPLL patients.
BMC Surgery, 2023 • June 3, 2023
This study aimed to investigate the risk factors for adjacent vertebral compression fractures (AVCF) after vertebroplasty and to establish a clinical prediction model. The study identified low bone ma...
KEY FINDING: Low bone mass density (BMD) is an independent risk factor for AVCF after vertebroplasty.
Biomedicines, 2023 • July 18, 2023
The study compares cytokine profiles in serum and tissues of patients with and without OPLL to identify potential biomarkers and understand the mechanisms behind ossification. The research identifies ...
KEY FINDING: Serum leptin levels are significantly higher in OPLL patients compared to non-OPLL patients, suggesting it may serve as a disease marker.
Cureus, 2023 • July 31, 2023
Diagnosis of low back pain combines old and new methodologies, in particular, it involves an expanded role for ultrasound. Tumors and infections are rarely involved in low back pain but should be rule...
KEY FINDING: Autologous blood products like platelet-rich plasma are safe and effective in stimulating the body’s regenerative responses for musculoskeletal pain.
Frontiers in Surgery, 2023 • September 11, 2023
Failed fracture healing remains a significant complication, and ongoing research aims to improve understanding of contributing factors at local and systemic levels. The immune system's role in bone he...
KEY FINDING: Interferon-gamma (IFN-y) signaling plays a key role in orchestrating immunological functions and serves an anabolic function in osseous biology, leading to osteoblastic activation.
Advanced Science, 2023 • October 23, 2023
This study investigates the use of hypoxic preconditioning to improve the therapeutic function of MSC-derived sEVs for treating IVD degeneration and chronic lower back pain. HP-sEVs were found to alle...
KEY FINDING: Hypoxic preconditioning enhances the therapeutic function of MSC-derived sEVs for IVD regeneration.
Frontiers in Physiology, 2023 • October 11, 2023
This study investigates the role of mechanical stimulation in heterotopic ossification (HOTL) using a mouse model with Enpp1 gene deficiency. The mice were subjected to spinal immobilization and tread...
KEY FINDING: Spinal immobilization effectively restricts the flexion and extension of cervical and thoracic vertebrae in mice, delaying spinal ligament ossification and reducing chronic secondary spinal cord injury.