Browse the latest research summaries in the field of orthopedics for spinal cord injury patients and caregivers.
Showing 381-390 of 452 results
J. Clin. Med., 2022 • April 11, 2022
The study investigated the effects of pre- and postconditioning with a TLR3 agonist (poly(I:C)) or shock wave therapy (SWT) on spinal cord ischemia (SCI) in cultured SHSY-5Y cells. TLR3 activation wit...
KEY FINDING: TLR3 activation via poly(I:C) significantly reduced apoptotic markers in both pre- and postconditioning, with preconditioning yielding more favorable results due to additional suppression of TLR4 signaling.
Nature Communications, 2022 • May 6, 2022
The study demonstrates that miR-17 has dual functions: maintaining cartilage homeostasis and protecting against OA. Decreased miR-17 expression in OA chondrocytes contributes to disease progression. I...
KEY FINDING: MiR-17 expression is decreased in osteoarthritic chondrocytes, and its deficiency contributes to OA progression.
European Journal of Trauma and Emergency Surgery, 2022 • May 21, 2022
This retrospective cohort study aimed to differentiate geriatric odontoid fractures into stable (SFs) and unstable fractures (UFs) based on angulation and displacement, correlating this classification...
KEY FINDING: The classification into SFs and UFs was significant for its angulation (P = 0.0006) and displacement (P < 0.0001).
Frontiers in Bioengineering and Biotechnology, 2022 • May 13, 2022
This editorial highlights the growing need for effective strategies to repair musculoskeletal tissue, especially tendon injuries and chronic tendinopathies. The special issue of Frontiers in Bioengine...
KEY FINDING: Pathological inflammation differs from reparative inflammation, and immunomodulatory therapies could be effective if timed correctly.
BMC Musculoskeletal Disorders, 2022 • June 3, 2022
This study compared two methods (GVR-A and GVR-B) for evaluating spinal cord hyperechogenicity intensity using intraoperative ultrasound (IOUS) in patients with degenerative cervical myelopathy (DCM) ...
KEY FINDING: GVR-B has better repeatability of gray value measurement, smaller relative standard deviation (RSD%) compared with GVR-A.
Cureus, 2022 • June 16, 2022
This review compiles recent data on collagen scaffolds for treating SCI in animal models. SCI presents significant challenges due to its economic and psychological impact. Studies using animals with s...
KEY FINDING: Collagen-based scaffolds, when transplanted, showed the most proliferation, and neural stem and progenitor cells survived up to 11 weeks after the transplant.
Frontiers in Neurology, 2022 • August 17, 2022
This review discusses the principles of ESWT, its cellular and molecular mechanisms, and its application in treating central and peripheral nervous system diseases based on animal and clinical studies...
KEY FINDING: ESWT can promote neural tissue regeneration and repairment in both the central and peripheral nervous systems, as demonstrated in animal studies of sciatic nerve injury, cerebral infarction, and spinal cord injury.
BMC Musculoskeletal Disorders, 2022 • September 6, 2022
The study evaluated cartilage measurements using T2 mapping and R2* sequences in monkeys with normal and reduced knee ROM to determine which sequence is better at detecting microstructural cartilage c...
KEY FINDING: MRI-R2* sequence is superior to T2 mapping in the detection of microstructural cartilage changes in knees with limited ROM.
International Journal of Spine Surgery, 2022 • October 12, 2022
This systematic review summarizes the existing literature regarding the use of amniotic membrane preparations, treatment regimens, and indications within spinal surgery. The review of reported studies...
KEY FINDING: Amnion products show promising effects in reducing epidural adhesions and scar tissue after spine surgery.
Orthopaedic Surgery, 2022 • December 1, 2022
This review synthesizes current research on resveratrol's (RSV) effects on intervertebral disc degeneration (IDD). It highlights RSV's potential to address the limitations of current IDD treatments by...
KEY FINDING: RSV exhibits anti-inflammatory effects by inhibiting pro-inflammatory cytokines like IL-1β, IL-6, IL-8, and TNF-α, which ameliorates IDD progression mediated by inflammation.