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  4. Comparison of Epidemiological Data of Complex Regional Pain Syndrome (CRPS) Patients in Relation to Disease Severity—A Retrospective Single-Center Study

Comparison of Epidemiological Data of Complex Regional Pain Syndrome (CRPS) Patients in Relation to Disease Severity—A Retrospective Single-Center Study

Int. J. Environ. Res. Public Health, 2023 · DOI: 10.3390/ijerph20020946 · Published: January 4, 2023

Pain ManagementOrthopedicsPublic Health

Simple Explanation

Complex Regional Pain Syndrome (CRPS) is a chronic pain condition that often affects a single limb, particularly the distal parts. Its exact cause is not fully understood, but it's believed to involve dysfunction in the central and peripheral nervous systems. The study aimed to identify specific factors that might increase the risk of developing CRPS, such as particular symptom patterns and demographic characteristics like age and gender. The researchers believed that by minimizing these factors, the overall risk of CRPS could be reduced. The study found that elderly women around 60 years old who experience a fracture in the hand or wrist after a fall, and who are then immobilized with a cast for about four weeks, are at a higher risk of developing CRPS.

Study Duration
11 Years
Participants
159 CRPS patients (116 women, 43 men)
Evidence Level
Not specified

Key Findings

  • 1
    The study confirmed a higher occurrence of CRPS in females. The hand and wrist were the most commonly affected areas, followed by the ankle and foot.
  • 2
    The most common symptoms observed were temperature differences, limited movement, and swelling in the affected area.
  • 3
    Prolonged cast immobilization might enhance the development of CRPS. About 58.5% of the patients studied had a cast for four weeks or longer.

Research Summary

This retrospective study analyzed data from 159 CRPS patients to identify epidemiological and clinical factors associated with the condition. The study population consisted mainly of women with an average age of 60.9 years. The most common trigger event for CRPS was trauma, particularly fractures treated either operatively or conservatively. The hand and wrist were the most frequently affected anatomical regions. The study concludes that elderly women with fractures in the hand or wrist, immobilized with a cast for approximately four weeks, are at a significantly higher risk of developing CRPS. Age and lower extremity involvement are also factors in CRPS severity.

Practical Implications

Early Diagnosis and Treatment

Prompt diagnosis and interdisciplinary treatment are critical for limiting CRPS progression and improving patients' quality of life.

Minimize Prolonged Immobilization

Modern implants and surgical aftercare should aim to avoid prolonged cast immobilization to reduce the risk of CRPS development.

Risk Factor Awareness

Clinicians should be aware of the elevated CRPS risk in elderly women with hand or wrist fractures requiring cast immobilization.

Study Limitations

  • 1
    Incomplete documentation of medical history and symptoms
  • 2
    Lack of standardized documentation due to multiple treating physicians
  • 3
    Some patients were referred externally with pre-existing conditions

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