Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 281-290 of 5,401 results
PLoS ONE, 2014 • February 11, 2014
This study investigates the expression of guidance and synaptogenic molecules in the cervical spinal cord of mice, both healthy and with spinal cord injuries, focusing on interneuron populations. The ...
KEY FINDING: Most of the guidance and synaptogenic molecules studied are present not only in the developing CNS but also in the adult CNS.
J. Vet. Med. Sci., 2014 • February 21, 2014
The study investigates the therapeutic potential of canine BMSC transplantation in mice with SCI. Results showed that BMSC therapy improved hind limb function and induced Nestin-positive cells at the ...
KEY FINDING: Canine BMSC transplantation enhanced functional recovery of the hind limbs in mice with SCI.
Cell Death and Differentiation, 2014 • February 21, 2014
This study investigates the role of Galectin-1 (Gal-1) in promoting axonal regeneration and functional recovery after spinal cord injury (SCI). The results demonstrate that Gal-1 binds to the NRP-1/Pl...
KEY FINDING: Galectin-1 (Gal-1) promotes full locomotor functional recovery and that an early intervention with this lectin was sufficient to prevent hindlimb loss of function after SCI.
Journal of Extracellular Vesicles, 2014 • February 19, 2014
This study investigates the effects of extracellular vesicles derived from muscle cells on motor neuron survival and neurite outgrowth, using the C2C12 muscle cell line and the NSC-34 motor neuron cel...
KEY FINDING: Extracellular vesicles from muscle cells significantly increase the average neurite length per neuron in motor neuron cultures.
Nat Commun., 2014 • January 1, 2014
This study demonstrates that resident astrocytes in the injured adult spinal cord can be manipulated to produce neurons by defined factors, raising the possibility of using these cells as a source for...
KEY FINDING: Ectopic SOX2 expression is sufficient to convert endogenous spinal astrocytes to proliferative DCX-positive neuroblasts in the injured adult spinal cord.
Neurosci Lett, 2014 • June 24, 2014
This study investigates the neuroprotective effects of bisperoxovanadium (bpV), a PTEN inhibitor, in a rat model of cervical spinal cord injury (SCI). The researchers hypothesized that bpV could incre...
KEY FINDING: bpV treatment promoted significant spared white matter (30%; p < 0.01).
PLoS ONE, 2014 • February 27, 2014
This study investigates the suitability of P(CL), P(TMC-CL) and P(TMC) as substrates for spinal cord regeneration purposes. The results show that P(TMC-CL) stimulates neuronal polarization and promote...
KEY FINDING: P(TMC-CL) films significantly increased neuronal polarization and axonal elongation compared to other tested polymers and a control.
PNAS, 2014 • March 3, 2014
The study demonstrates that blood-spinal cord barrier (BSCB) breakdown contributes to early motor-neuron degeneration in ALS mice. Restoring BSCB integrity during an early disease phase retards the di...
KEY FINDING: Early motor-neuron dysfunction and injury are proportional to the degree of BSCB disruption in SOD1G93A mice.
Neurosurgery, 2014 • July 1, 2014
This study investigates the role of NgR1 in limiting axon regeneration after spinal cord injury (SCI). Using mice with varying degrees of NgR1 deficiency and SCI severity, the research aimed to clarif...
KEY FINDING: The level of functional recovery is affected by the degree of injury suffered, with NgR1 ablation leading to significant recovery in locomotor function following severe SCI.
The Journal of Neuroscience, 2014 • March 5, 2014
This study investigates the distribution of VGLUT1 synapses on motoneurons before and after peripheral nerve injury and regeneration in rats. The researchers mapped the location of these synapses alon...
KEY FINDING: In healthy motoneurons, VGLUT1 synapses are mainly located on proximal dendrites, grouped in tight clusters.