Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 291-300 of 5,401 results
Curr Opin Neurobiol, 2014 • August 1, 2014
The Nogo-A and NgR1 signalling cascade have been studied extensively with regard to neurological trauma. Blockade of these pathways leads to greater functional recovery through a combination of neural...
KEY FINDING: Targeting the Nogo-A/NgR1 pathway has demonstrated effectiveness in promoting functional recovery and neural repair following various CNS injuries, including spinal cord trauma, stroke, and optic nerve damage.
PLoS ONE, 2014 • March 25, 2014
This study investigates the regulation of Interleukin-6 (IL-6) secretion by astrocytes after spinal cord injury (SCI). It identifies the PI3K-mTOR-Calcium signaling pathway as a key regulator of IL-6 ...
KEY FINDING: IL-6 is expressed by astrocytes, neurons, and microglia/macrophages in the spinal cord after contusion injury.
PLoS ONE, 2014 • March 25, 2014
This study evaluated the neuroprotective and neuroregenerative properties of NX210, a peptide derived from SCO-spondin, in vitro and in vivo for the treatment of spinal cord injury (SCI). In vitro stu...
KEY FINDING: NX210 provides neuroprotection against oxidative stress in B104 neuroblastoma cells in vitro.
Stem Cell Reports, 2014 • March 11, 2014
The study demonstrates the existence of intrinsically active neurons (IANs) in pluripotent stem cell-derived neuronal networks, using mouse embryonic stem cells. These IANs are functionally integrated...
KEY FINDING: Pluripotent stem cell-derived neuronal networks contain intrinsically active neurons (IANs) that remain active after blocking fast synaptic communication.
Neuroscience Letters, 2014 • March 12, 2014
This study investigates the use of a novel fibrin scaffold for delivering MSCs to injured spinal cords, aiming to improve cell integration and control compared to intraspinal injection. The results sh...
KEY FINDING: Fibrin scaffold delivery of MSCs results in longitudinally-aligned layers of cells at the injury site.
Brain and Behavior, 2014 • March 1, 2014
This study investigates the effects of Fgf2 treatment on spinal cord injury (SCI) in mice, focusing on its impact on glial scarring, neuronal survival, and neurite outgrowth. The research aims to iden...
KEY FINDING: Fgf2 treatment decreases the expression of TNF-α, reduces monocyte/macrophage infiltration, and decreases gliosis at the lesion site after spinal cord injury in mice.
Molecular Brain, 2014 • March 31, 2014
In 2006, we demonstrated that mature somatic cells can be reprogrammed to a pluripotent state by gene transfer, generating induced pluripotent stem (iPS) cells. Since that time, there has been an enor...
KEY FINDING: When mouse or human iPS cells were induced to form NS/PCs and were transplanted into mouse or non-human primate SCI models, long-term restoration of motor function was induced, without tumorigenicity, by selecting a suitable iPS cell line.
The Journal of Neuroscience, 2014 • April 2, 2014
This study demonstrates that gene delivery of mammalian-compatible ChABC leads to large-scale digestion of CSPGs in the spinal cord, resulting in neuroprotection and long-term improved functional outc...
KEY FINDING: LV-ChABC treatment significantly reduced cavitation and enhanced the preservation of spinal neurons and axons at 12 weeks post-injury, compared with control-treated animals.
Exp Neurol, 2014 • June 1, 2014
This study investigates the role of dbx1a-expressing radial glial progenitors in spinal cord regeneration in zebrafish larvae. The researchers demonstrate that these progenitors persist beyond embryog...
KEY FINDING: The dbx1a:GFP reporter labels radial glial progenitors in the zebrafish spinal cord beyond embryogenesis, indicating their prolonged presence and potential role in regeneration.
J. Exp. Med., 2014 • May 5, 2014
This study investigates the role of B-RAF kinase in promoting axon growth and regeneration in both the peripheral and central nervous systems using conditional gain-of-function mouse models. The resea...
KEY FINDING: Conditional activation of B-RAF kinase alone in mouse embryonic neurons is sufficient to drive the growth of long-range peripheral sensory axon projections in vivo without upstream neurotrophin signaling.