Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 271-280 of 5,401 results
Journal of Otolaryngology - Head and Neck Surgery, 2013 • December 19, 2013
The study investigates the combinatorial effect of neural precursor cells (NPCs) and self-assembling peptides (SAPs) on nerve regeneration after spinal cord injury in rats. Results showed that SAP + N...
KEY FINDING: SAP + NPC transplantation significantly improved locomotor score compared to control groups.
J. Cell. Mol. Med., 2014 • February 1, 2014
The study investigates the cytoprotective effects of 17b-estradiol (E2) on human eyelid adipose-derived stem cells (hEASCs) against oxidative stress induced by hydrogen peroxide (H2O2) in vitro and in...
KEY FINDING: E2 protects hEASCs against H2O2-induced cell death in vitro.
JOURNAL OF NEUROTRAUMA, 2014 • May 1, 2014
This study investigates the effects of ChABC treatment on astrogliosis and revascularization after spinal cord injury (SCI) in rats. The researchers injected ChABC intrathecally after a spinal cord he...
KEY FINDING: ChABC treatment effectively cleaves CSPG glycosaminoglycan chains and stimulates axonal remodeling within the injury site, accompanied by an extended period of astrocyte remodeling.
Journal of Clinical and Diagnostic Research, 2013 • November 10, 2013
This study focused on isolating Globose Basal Cells (GBCs) from the olfactory mucosa of Albino Wistar rats, as these cells possess the ability to regenerate olfactory mucosa throughout life. The chall...
KEY FINDING: The study standardized techniques for isolating GBCs from rat olfactory mucosa using GBC-III antibody and FACS.
PLoS ONE, 2014 • January 3, 2014
This study investigates the role of ADAM10 in spinal cord development, finding that its downregulation leads to precocious neuronal differentiation. The mechanism involves ADAM10's metalloprotease dom...
KEY FINDING: Downregulation of ADAM10 drives precocious differentiation of neural progenitor cells and radial glial cells, resulting in an increase of neurons in the developing spinal cord.
The Journal of Neuroscience, 2014 • January 29, 2014
The study investigates the effects of transplanting Schwann cells (SCs) genetically modified to secrete a bifunctional neurotrophin (D15A) and chondroitinase ABC (ChABC) into a subacute contusion inju...
KEY FINDING: Transplantation of SCs secreting both D15A and ChABC yielded the best responses including the largest number of SC myelinated axons and more propriospinal axons.
PLoS ONE, 2014 • February 3, 2014
This study introduces the use of self-complementary adeno-associated virus serotype 2 (scAAV2) as an effective tracer for labeling axons, demonstrating its ability to efficiently transduce neurons and...
KEY FINDING: scAAV2-GFP efficiently transduces neurons in the sensorimotor cortex, red nucleus, and DRG, with strong GFP expression transported anterogradely along axons to label numerous axon fibers from CST, RST, and central axons of DRG.
Journal of Anatomy, 2014 • February 7, 2014
This study examined the role of c-Jun activation in neonatal rat motoneurons after nerve crush injury, observing both degeneration and regeneration. The key finding was that all injured motoneurons in...
KEY FINDING: Nerve crush injury in neonatal rats leads to two distinct outcomes for motoneurons: approximately 60% undergo degeneration, while 40% survive and regenerate.
Spine J., 2014 • September 1, 2014
This pilot study demonstrated that a PLGA scaffold improved regeneration of axons into peripheral nerve roots. The channels in the scaffold served as a mechanical bridge for axons to regenerate betwee...
KEY FINDING: The PLGA scaffold treatment group showed a statistically significant improvement in axon regeneration through the injury compared to the control group.
Mol Cell Neurosci, 2014 • March 1, 2014
This study demonstrates that JUN can promote axon growth and regeneration in cortical neurons, and suggests that it does so in a way that is mechanistically distinct from what is observed in periphera...
KEY FINDING: The Jun oncogene/signal transducer and activator of transcription 6 (JUN/STAT6) combination increased neurite growth in dissociated cortical neurons and in injured cortical slices.