Poly(Trimethylene Carbonate-co-e-Caprolactone) Promotes Axonal Growth

This study explores the potential of several polymers, including poly(trimethylene carbonate-co-e-caprolactone) or P(TMC-CL), to support nerve regeneration, particularly in the context of spinal cord injuries. The researchers tested how well nerve cells adhere to and grow on films made from these polymers, finding that P(TMC-CL) significantly enhanced nerve cell polarization and axon elongation. Further experiments showed P(TMC-CL) helped neurons extend fibers even when exposed to myelin, a substance that usually inhibits nerve growth. This positive effect appears to be linked to a specific signaling pathway inside the cells.

• 1
  P(TMC-CL) films significantly increased neuronal polarization and axonal elongation compared to other tested polymers and a control.
• 2
  Cortical neurons cultured on P(TMC-CL) were able to extend neurites even when seeded onto myelin, indicating an overcoming of myelin inhibition.
• 3
  The beneficial effects of P(TMC-CL) on axonal growth are mediated by the glycogen synthase kinase 3b (GSK3b) signaling pathway.