PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury

This study investigates the effects of bisperoxovanadium (bpV), a PTEN inhibitor, on spinal cord injury in rats. PTEN inhibition promotes neural cell survival and myelination. The study found that bpV treatment led to increased white matter and myelin around the injury site. This suggests that bpV may help protect or repair the myelin sheath around nerve fibers. Additionally, bpV treatment increased the number of oligodendrocytes, cells responsible for producing myelin, and reduced atrophy of motor neurons. These findings suggest bpV promotes tissue sparing and reduces cell damage.

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  bpV treatment promoted significant spared white matter (30%; p < 0.01).
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  bpV treatment increased Luxol Fast Blue (LFB)+ myelin area rostral and at the epicenter (p < 0.05).
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  VLF oligodendrocytes were also significantly greater with bpV therapy (109 ± 5.3 vs. Veh: 77 ± 2.7/mm2; p < 0.01).