Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis

Cell therapy and regenerative medicine offer promise in restoring tissue structure and function, especially for chronic diseases like osteoporosis, which causes bone loss and increases fracture risk. Current osteoporosis treatments mainly prevent bone loss, but stem cell therapy is a new approach for bone tissue regeneration. Mesenchymal stem cells (MSCs) are preferred due to their anti-inflammatory properties and fewer ethical concerns. MSCs' effectiveness largely depends on their ability to secrete substances that initiate molecular signaling pathways for normal bone remodeling. This review focuses on the effects of stem cell-based therapies in osteoporosis.

• 1
  Mesenchymal stem cells (MSCs) are pivotal candidates for bone regeneration due to their anti-inflammatory and immune-privileged potential, making them ethically less concerning than other stem cell types.
• 2
  MSCs can establish normal bone remodeling by initiating specific molecular signaling pathways, with their effectiveness largely dependent on their secretory function.
• 3
  Cell-based regenerative medicine aids osteoporosis treatment by modulating bone resorption, reducing fracture susceptibility, and enhancing mineral density through improved stem cell function.