Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 141-150 of 278 results
Cureus, 2022 • December 19, 2022
This case report describes the rehabilitation of a 45-year-old male with paraplegia and an intertrochanteric fracture. The patient had a history of spinal cord injury and sustained the fracture during...
KEY FINDING: Physiotherapy plays a crucial role in the postoperative management of intertrochanteric fractures in paraplegic patients. It helps prevent complications like bed sores, joint stiffness, muscle wasting, and pulmonary issues.
International Journal of Medical Sciences, 2023 • January 31, 2023
The study investigates the role of Numb and Notch signaling in denervation atrophy of skeletal muscle in mice, using nandrolone treatment and conditional knockout models. Results showed that nandrolon...
KEY FINDING: Nandrolone treatment increased Numb expression and reduced Notch signaling in denervated muscle.
Frontiers in Nutrition, 2023 • March 3, 2023
This review summarizes the pathophysiological changes of skeletal muscle atrophy after SCI, analyzes the related factors and atrophy mechanisms, providing a theoretical basis and research direction fo...
KEY FINDING: Inflammation and oxidative stress are major mechanisms driving skeletal muscle atrophy after spinal cord injury.
PLoS ONE, 2016 • December 1, 2016
This study investigated microRNA (miR) expression profiles in paralyzed gastrocnemius muscle of rats after spinal cord injury (SCI) compared to sham-operated rats to understand the mechanisms behind m...
KEY FINDING: miRs 23a, 23b, 27b, 145, and 206, were downregulated in skeletal muscle 56 days after SCI.
Photoacoustics, 2021 • March 10, 2021
This study demonstrates the feasibility of using photoacoustic time-frequency spectral analysis (PA-TFSA) to characterize bone mineral density (BMD) and bone microstructure. The results show that oste...
KEY FINDING: Osteoporotic bone samples with lower BMD and thinner MTT exhibit higher frequency components in PA-TFSA.
The Journal of Spinal Cord Medicine, 2014 • January 1, 2014
This study assessed bone mineral density (BMD) in Iranian patients with chronic spinal cord injury (SCI), examining the impact of demographic, injury-related, and dietary factors. The research involve...
KEY FINDING: Older male patients exhibited lower BMD specifically in spinal vertebrae.
The Journal of Spinal Cord Medicine, 2015 • January 1, 2015
This retrospective study investigated the protective effect of oral alendronate (ALN) intake on the appearance of heterotopic ossification (HO) in patients with spinal cord injury (SCI). The study fou...
KEY FINDING: There was no statistically significant difference in the incidence of HO in patients receiving oral ALN compared to those not receiving it.
Osteoporos Int, 2014 • November 1, 2014
The study explored the association between adiponectin levels and bone strength in paralyzed men with spinal cord injury, finding an inverse relationship between bone strength and circulating adiponec...
KEY FINDING: Axial stiffness and maximal load were inversely associated with circulating adiponectin levels after adjusting for injury duration and lower extremity lean mass.
J Clin Densitom, 2015 • January 1, 2015
The study compares two methods for segmenting muscle from fat in pQCT scans: threshold-based edge detection and a watershed algorithm-guided manual segmentation. The watershed algorithm showed superio...
KEY FINDING: The watershed segmentation method demonstrated lower precision error compared to the threshold-based edge detection method across all participant groups.
Annals of Rehabilitation Medicine, 2014 • August 1, 2014
This case report describes rhabdomyolysis in a spinal cord injury patient presenting with nausea and vomiting. Early diagnosis of rhabdomyolysis through regular creatine kinase level checks can help p...
KEY FINDING: The patient with acute spinal cord injury presented with rhabdomyolysis, but the primary symptoms were nausea and vomiting, not the typical muscle pain or dark urine.