Denervation Atrophy of Skeletal Muscle is Not Influenced by Numb Levels in Mice

This study investigates the role of Numb, a protein involved in muscle repair and function, in denervation atrophy, which is muscle wasting due to nerve damage. The researchers explored whether increasing Numb levels or preventing its decrease could slow down this atrophy process in mice. The study also examined the involvement of Notch signaling, a pathway known to affect muscle growth and breakdown, in denervation atrophy. They tested whether manipulating Notch signaling, along with Numb levels, could influence the rate of muscle wasting. The findings suggest that neither manipulating Numb levels nor blocking Notch signaling significantly alters the rate of denervation atrophy in mice. This indicates that these factors may not be key drivers of muscle wasting in this specific context.

• 1
  Nandrolone treatment increased Numb expression and reduced Notch signaling in denervated muscle.
• 2
  Neither nandrolone alone nor nandrolone plus testosterone changed the rate of denervation atrophy in mice.
• 3
  Conditional knockout of Numb in myofibers did not alter the rate of denervation atrophy.