Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 121-130 of 278 results
Top Spinal Cord Inj Rehabil, 2020 • January 1, 2020
Individuals with spinal cord injury/disorder (SCI/D) are at high risk for developing secondary osteoporosis, with bone loss being multifactorial and dependent on the time from and extent of neurologic...
KEY FINDING: Most bone loss occurs in the first year following neurologic injury and continues for years after.
Indian Journal of Orthopaedics, 2020 • June 2, 2020
This randomized controlled trial assessed the effect of early zoledronic acid administration on bone loss in acute SCI patients. aBMD was measured at the forearm at baseline and at 3, 6, and 12 months...
KEY FINDING: Significant differences in aBMD were found between the control and Zoledronic acid groups at various forearm sites in paraplegic patients one year after SCI.
Bone, 2021 • January 1, 2021
This study examined the incidence of musculoskeletal disorders in adults with spinal cord injuries (SCIs) compared to those without. The findings revealed a significantly higher incidence of musculosk...
KEY FINDING: Adults with SCIs had a significantly higher incidence of any musculoskeletal morbidities (82.4% vs. 47.5%) compared to those without SCIs.
JBMR Plus, 2020 • August 1, 2020
This study evaluated the effectiveness of denosumab in preserving bone mineral density (BMD) in individuals with subacute spinal cord injury (SCI). The findings indicate that denosumab maintained BMD ...
KEY FINDING: Denosumab maintained aBMD at the distal femur and proximal tibia in persons with a subacute motor-complete SCI.
Bone, 2021 • March 1, 2021
This study investigated the effects of electrical stimulation (ES) and/or testosterone enanthate (TE) on muscle mass and bone formation in a rat model of spinal cord injury (SCI). The results demonstr...
KEY FINDING: ES alone or ES+TE treatment resulted in a clear and significant (~13%, p<0.05) increase of the left EDL muscle mass.
Ann Rehabil Med, 2021 • February 9, 2021
This study investigated the correlation between bone mineral density (BMD) and the duration of spinal cord injury (SCI) in individuals, while adhering to the 2007 International Society for Clinical De...
KEY FINDING: A significant negative correlation was found between the duration from injury and femur neck BMD Z-score (r=-0.40, p<0.01).
Spinal Cord Series and Cases, 2021 • January 1, 2021
The study assessed clinical practice patterns regarding osteoporosis assessment and management in an international cohort of SCI professionals and compared them to those advanced by professional socie...
KEY FINDING: Professionals were equally likely to test for bone loss during the post-acute phase (between 4- and 18-months post injury) and after low impact fracture (41.46% and 42.68%, respectively) and more likely to test during the chronic phase (51.22%).
Physiological Reports, 2021 • January 12, 2021
This study aimed to determine if SS-31, a mitochondrial-targeting peptide, could prevent muscle loss after SCI in mice. A 50 kdyne contusion SCI model was used, and mice were administered daily inject...
KEY FINDING: A 50 kdyne contusion SCI in young male mice resulted in decreased body mass and loss of mass in plantaris and gastrocnemius muscles.
Spinal Cord Series and Cases, 2021 • March 4, 2021
This case report presents the successful treatment of bilateral sacral insufficiency fractures with sacroplasty in a 52-year-old male with chronic complete tetraplegia experiencing intractable autonom...
KEY FINDING: Sacroplasty resulted in immediate resolution of autonomic dysreflexia (AD) in a patient with chronic tetraplegia and bilateral sacral insufficiency fractures.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
Spinal cord injury (SCI) results in dramatic changes in body composition, with lean mass decreasing and fat mass increasing in specific regions that have important cardiometabolic implications. The re...
KEY FINDING: SCI leads to regionally specific changes in body composition, with increased adiposity around the viscera, skeletal muscle, and bone marrow.