Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 691-700 of 730 results
ACS Omega, 2020 • June 25, 2020
This study investigated the anti-inflammatory effects of bFGF and DPSCs, delivered via a thermosensitive hydrogel, in a rat model of spinal cord injury. The results showed that the combined use of bFG...
KEY FINDING: bFGF and DPSCs together effectively attenuate tissue inflammation in the injured spinal cord, leading to better nerve repair.
Translational Psychiatry, 2020 • July 15, 2020
The study investigated neuroinflammatory alterations in high trait anxiety using a mouse model (HAB). Results showed increased microglial density and activity in the hippocampus of HAB mice, particula...
KEY FINDING: HAB mice exhibited enhanced density and average cell area of Iba1+ microglia in the dentate gyrus (DG) of the hippocampus compared to NAB controls.
Acta Neuropathologica Communications, 2020 • January 1, 2020
The study investigates the role of microglia in leukotriene (LT) biosynthesis in the context of Alzheimer's Disease (AD). It identifies the key enzyme 5-Lipoxygenase (5-Lox) primarily in neurons and t...
KEY FINDING: FLAP, a key activator of the LT pathway, is found in all microglia and no other brain cells.
Journal of Neuroinflammation, 2020 • August 25, 2020
Following SCI, neuronal pyroptosis lasted longer and occurred farther away from the injury core compared with that of neuronal apoptosis. Microglial Hv1 deficiency downregulated microglial ROS generat...
KEY FINDING: Neuronal apoptosis peaked earlier than pyroptosis after SCI, but pyroptosis lasted longer.
Nature Communications, 2020 • September 9, 2020
This study presents a pH-responsive immunomodulatory strategy for neural regeneration using electrospun fibers that release IL-4 plasmids to suppress inflammation and promote neural differentiation. T...
KEY FINDING: The microenvironment-responsive immunoregulatory electrospun fibers were able to shift immune cell subtypes to down-regulate the acute inflammation response.
Frontiers in Immunology, 2020 • August 14, 2020
This mini-review discusses the role of fibrotic scar formation in neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Alzheimer’s disease (AD). The r...
KEY FINDING: Fibrotic scarring in neurodegenerative diseases like ALS, MS, and AD involves complex interactions between various cell types, including astrocytes, microglia, fibroblasts, and immune cells.
Neural Regeneration Research, 2021 • September 22, 2020
This review discusses the potential of targeting Epac2, a downstream effector of cAMP, as a therapeutic strategy for traumatic spinal cord injury (TSCI). Epac2 is mainly expressed postnatally in the C...
KEY FINDING: Epac2 activation can modulate the post-lesion environment following traumatic spinal cord injury, decreasing the activation of astrocytes and microglia.
Neurotherapeutics, 2021 • October 16, 2020
This study investigates the neuroprotective ability of systemic administration of AMP cells on clinical disease progression and histopathology of optic neuritis and myelitis in EAE mice. The results d...
KEY FINDING: Systemic administration of AMP cells significantly reduced ascending paralysis in EAE mice.
Nat Immunol, 2020 • December 1, 2020
The study identifies a novel myeloid cell phenotype with neuroprotective and axonogenic properties that arises in the setting of optic nerve and spinal cord injury. This reparative cell is a CD14+Ly6G...
KEY FINDING: A unique granulocyte subset, characterized as an immature neutrophil, exhibits neuroprotective properties and drives CNS axon regeneration in vivo.
Cellular & Molecular Immunology, 2020 • October 27, 2020
This study investigates the effects of the small-molecule TPN10456 on Th17 cell differentiation and its potential therapeutic role in multiple sclerosis (MS). The research demonstrates that TPN10456 ...
KEY FINDING: TPN10456 inhibits Th17 cell differentiation in a dose-dependent manner. The addition of TPN10456 resulted in a dose-dependent reduction in the frequency of IL-17A-producing cells.