Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 681-690 of 730 results
Neural Regeneration Research, 2020 • January 9, 2020
N-formyl peptide receptors (FPRs) were first identified upon phagocytic leukocytes, but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor family. Rapid...
KEY FINDING: FPRs are implicated in neurogenesis and neuronal differentiation, suggesting they could be a target for neuronal regeneration therapies.
Nat Neurosci., 2020 • March 1, 2020
This process involves corralling, wherein phagocytic immune cells become confined to the necrotic core surrounded by an astrocytic border. Plexin-B2 regulates corralling and wound compaction by enhanc...
KEY FINDING: Plexin-B2 is upregulated in injury-activated microglia and macrophages (IAM) after SCI.
PLoS ONE, 2020 • March 10, 2020
This study investigates the effects of human mesenchymal stem/stromal cells (hMSCs) on spinal cord injury (SCI) recovery in mice, focusing on the roles of chemokines CCL2/CCR2 and CCL5/CCR5. The resea...
KEY FINDING: hMSC transplantation enhanced Ccl2 and Ccl5 expression and improved locomotor activity in mice with SCI.
Journal of Molecular Neuroscience, 2020 • March 23, 2020
The study investigates the role of alpha-Synuclein (aSyn) in CNS demyelination using EAE and cuprizone models in aSyn-deficient mice. Results indicate that aSyn deficiency ameliorates EAE severity by ...
KEY FINDING: In the EAE model, aSyn-deficient mice showed a significant reduction of CNS inflammation and decreased myelin loss during late-stage inflammatory demyelination.
Journal of Infection, 2020 • March 3, 2020
This letter to the editor discusses a study on the impact of low-dose corticosteroid therapy on viral clearance in COVID-19 patients. The study analyzed data from 78 patients and found no significant ...
KEY FINDING: Low-dose corticosteroid therapy does not significantly delay viral clearance in patients with COVID-19.
CNS Neuroscience & Therapeutics, 2020 • July 1, 2020
This study investigated the neurogenic effects of immunization with neural-derived peptides (INDP) in rats with chronic spinal cord injury (SCI). The results demonstrated that INDP treatment led to si...
KEY FINDING: INDP treatment significantly improved both motor and sensory recovery in rats with chronic SCI compared to the control group.
Journal of Neuroinflammation, 2020 • May 8, 2020
This study explored the protective role of ATO on MOG35–55-induced EAE mice. The results suggested that ATO delayed the onset of EAE, alleviated the clinical signs and severity of EAE in mice, reduced...
KEY FINDING: ATO delayed the onset of EAE and alleviated the severity of EAE in mice.
Journal of Neuroinflammation, 2020 • April 13, 2020
This study investigates the role of IL-20, a proinflammatory cytokine, in spinal cord injury (SCI) in rats. The researchers examined the expression of IL-20 and its receptors after SCI and explored it...
KEY FINDING: IL-20 and its receptors are expressed in astrocytes, oligodendrocytes, and microglia in the spinal cord after SCI in rats.
Exp Cell Res, 2020 • September 15, 2020
This study used single-cell transcript sequencing to identify gene expression markers for specific immune cell types, including erythrocytes, neutrophils, macrophages, and lymphocytes, in axolotl bloo...
KEY FINDING: Six cell populations were identified from peripheral leukocytes presenting gene expression patterns indicative of erythrocyte, thrombocyte, neutrophil, B-cell, T-cell, and myeloid cell populations.
Cell Tissue Bank, 2020 • June 25, 2020
COVID-19, characterized by severe acute respiratory infections (ARIs), poses a significant global health challenge, with no specific treatment available to date beyond symptom relief. The excessive im...
KEY FINDING: MSCs can regulate the proliferation and activation of immune cells and differentiate into type II alveolar epithelial cells, which are crucial for lung function.