Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 701-710 of 730 results
Front. Aging Neurosci., 2020 • September 23, 2020
This review explores the role of the adaptive immune system in neurodegenerative diseases, highlighting its involvement in both degeneration and regeneration processes. Aging is identified as a key fa...
KEY FINDING: Adaptive immune cells, particularly T lymphocytes, can have both detrimental and beneficial roles in neurodegenerative diseases, influencing both degeneration and regeneration.
Journal of Neuroinflammation, 2021 • January 12, 2021
This study demonstrates that microglial inflammation after spinal cord injury is enhanced by reactive astrocytes through the fibronectin/β1 integrin pathway. Administration of β1Ab can ameliorate both...
KEY FINDING: β1Ab treatment altered microglial distribution within the glial scar after SCI, promoting a more even distribution instead of concentration in the lesion core.
Clin. Transl. Med., 2021 • December 29, 2020
This study investigates the role of CD73 in alleviating GSDMD-mediated microglia pyroptosis in spinal cord injury (SCI) through the PI3K/AKT/Foxo1 signaling pathway. The research demonstrates that CD7...
KEY FINDING: CD73 suppresses the activation of NLRP3 inflammasome complexes to reduce the maturation of GSDMD, leading to decreased pyroptosis in microglia.
Frontiers in Microbiology, 2021 • January 8, 2021
The study optimized the CRISPR/Cas system for genome editing in Plasmodium falciparum by developing an integrating strategy (Cas9i) and adapting the CRISPR/Cpf1 system. The Cas9i system significantly ...
KEY FINDING: The Cas9i system significantly shortened the time required to generate transgenic strains of P. falciparum.
Nat Neurosci, 2021 • February 1, 2021
This study demonstrates the presence of a fibrotic scar in the CNS following immune cell infiltration in a mouse model of multiple sclerosis, suggesting a common response to injury and inflammation ac...
KEY FINDING: A robust Col1+ fibrotic scar forms in response to immune cell infiltration in the CNS, specifically in neuroinflammatory lesions.
Front. Aging Neurosci., 2021 • February 9, 2021
This study investigated the role of immune cell infiltration in Parkinson's disease (PD) by analyzing transcriptomic datasets from the substantia nigra of PD patients and healthy controls. The study i...
KEY FINDING: The study identified 10 types of immune cells with significantly different infiltration levels between PD patients and healthy controls, including activated B cells, CD56 bright natural killer cells, and mast cells.
Frontiers in Immunology, 2021 • February 19, 2021
This study examined the impact of individual TnC fragments on astrocytic physiology in vitro and in vivo after spinal cord injury (SCI). The results indicated that TnC fragments delay gap closure in v...
KEY FINDING: TnC fragments delay gap closure in astrocyte cultures, primarily by reducing astrocyte proliferation. The most potent fragments were FnD, FnA, and their combination.
Theranostics, 2021 • February 20, 2021
This study investigates the role of SARM1 in spinal cord injury (SCI) using conditional knockout mice. The researchers found that SARM1 is upregulated in neurons and astrocytes after SCI, promoting ne...
KEY FINDING: SARM1 was upregulated in neurons and astrocytes at the early stage after SCI.
Journal of Neuroinflammation, 2021 • March 23, 2021
The study investigates the role of CRYAB, a small heat shock protein, in the immune response following peripheral nerve injury, focusing on macrophages. Results show that Cryab−/− mice exhibit a prolo...
KEY FINDING: More pro-inflammatory CD16/32+ macrophages are present in the nerves of Cryab−/− mice at days 14 and 21 after sciatic nerve crush-injury compared to WT counterparts.
Journal of Inflammation Research, 2021 • January 1, 2021
This study aimed to determine the incidence of occult infections (OI) in patients receiving autologous bone grafting (ABG) for non-union (NU) treatment, evaluate its impact on the outcome, and identif...
KEY FINDING: The incidence of occult infections after non-union treatment of the lower limb remains at 9.04% despite thorough preoperative screening.