Immunology Research

KEY FINDING: hIgG (2 g/kg) protected the spinal cord neurovasculature after SCI by increasing tight junction protein expression and reducing inflammatory enzyme expression.

KEY FINDING: ECM hydrogels, particularly in solubilized form, can modulate inflammation in LPS-stimulated microglial cells, with spinal cord-derived hydrogels reducing the Nos2/Arg1 ratio and bone-derived hydrogels reducing Tnf expression.

KEY FINDING: Pramipexole, a dopamine agonist, was identified as a specific enhancer of zTreg recruitment to injured tissue in zebrafish.

KEY FINDING: SCI leads to gut dysbiosis, characterized by changes in the composition and abundance of gut bacteria, such as a decrease in Bacteroidales and an increase in Clostridiales.

KEY FINDING: Tempol treatment promoted greater neuronal survival (23%) at the initial stage of symptoms compared to untreated animals, and this was maintained until the end stage.

KEY FINDING: Foam cells (foamy macrophages) accumulate in the invasive fibrotic meninges during gap regeneration of transected adult Axolotl spinal cord and may act beneficially.

KEY FINDING: IgE-selective IA effectively reduced serum IgE levels in all participants by an average of 81% per cycle.

KEY FINDING: BMSCs from both adult and elderly donors met standard criteria for MSCs, exhibiting similar morphology, growth kinetics, gene expression profiles, and differentiation capacity.

KEY FINDING: Increased numbers of CD8+ TEMRA cells were found in the peripheral blood of patients with MCI or AD, and these cells were negatively associated with cognition.

KEY FINDING: Microglia in aged mouse and human brains accumulate lipid droplets, forming lipid droplet-accumulating microglia (LDAM).