Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 651-660 of 730 results
Frontiers in Neurology, 2018 • May 15, 2018
The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein MOG-IgG, can be challenging because of atypical clinical presentation (1–3). To co...
KEY FINDING: The patient was MOG-IgG-positive and experienced progressive neurological deterioration after two episodes of ON.
Neural Regen Res, 2018 • May 1, 2018
This study investigated the expression of Nogo receptors (NgR) within microglia/macrophage populations during the progression of experimental autoimmune encephalomyelitis (EAE), an animal model of mul...
KEY FINDING: A significant difference in microglia/macrophage numbers between ngr1+/+ and ngr1–/– mice was identified during EAE progression, but this difference was unrelated to NgR expression on these cells.
Biol Blood Marrow Transplant, 2018 • July 1, 2018
The study highlights significant variability in MSC manufacturing protocols across European centers, impacting the consistency of clinical products. Key variations were identified in tissue sources, c...
KEY FINDING: Most centers use bone marrow as the source for MSCs, but there's a shift from fetal bovine serum to human platelet lysate as a medium supplement.
Neural Regeneration Research, 2018 • August 1, 2018
This study examined the impact of matrix metalloproteinase (MMP) inhibition on macrophage migration and spinal function recovery in rats with completely transected spinal cords treated with fibroblast...
KEY FINDING: MMP-9, but not MMP-2, was upregulated in the graft area of rats treated with fibroblast growth factor-1 and peripheral nerve grafts, suggesting a role in the regenerative process.
Journal of Neuroinflammation, 2018 • September 3, 2018
This study investigates the role of microglia in Alzheimer's disease (AD) by ablating these cells in APP-PS1 transgenic mice and examining the consequences on AD pathology and peripheral immune cell i...
KEY FINDING: PLX5622 treatment successfully reduced microglia numbers but uncovered a treatment-resistant macrophage population (Iba1+/TMEM119−) that strongly expressed the phagocytosis marker CD68 and the lymphocyte activation, homing, and adhesion molecule CD44, specifically at sites of amyloid-beta plaques in the brains of APP-PS1 mice.
Nature Communications, 2018 • November 6, 2018
The study demonstrates that spinal cord injury leads to an inflammatory response that promotes axonal regeneration. Inhibiting inflammation reduces the number of immune cells and impairs axonal bridgi...
KEY FINDING: Inhibiting inflammation reduces and promoting inflammation accelerates axonal regeneration in spinal-lesioned zebrafish larvae.
Frontiers in Neurology, 2018 • November 20, 2018
The study investigates the potential of prior regular exercise to modify the effects of pharmacological treatments, specifically glatiramer acetate (GA) and dimethyl fumarate (DMF), in a murine model ...
KEY FINDING: Exercised-GA treated animals demonstrated decreased astrocytic response in the spinal dorsal horn with an improvement in the paw print pressure.
Neural Regen Res, 2019 • March 1, 2019
The study investigates the spatio-temporal expression of AIM2 in normal and injured spinal cords of rats after contusive SCI. AIM2 expression increases significantly in the early phase (1 hour to 1 da...
KEY FINDING: AIM2 protein expression significantly increased at 1 hour, 6 hours, and 1 day post-spinal cord injury compared to sham-operated rats.
Theranostics, 2018 • October 27, 2018
This study identifies new translational targets for PET tracers that can image the anti-inflammatory/protective activation state of microglia. The study demonstrates the potential of a rationale-based...
KEY FINDING: P2RY12 expression increases in murine and human microglia following exposure to anti-inflammatory stimuli.
Nat Neurosci, 2019 • March 1, 2019
This study elucidates a previously unrecognized function of microvascular endothelial cells in engulfing myelin debris following neural injury, specifically in SCI and EAE models. The process requires...
KEY FINDING: Microvascular endothelial cells act as amateur phagocytes to engulf myelin debris in SCI and EAE, requiring IgG opsonization for effective uptake.