Progressive Demyelination in the Presence of Serum Myelin Oligodendrocyte Glycoprotein-IgG: A Case Report

This case report describes a patient with progressive demyelinating opticospinal disease, IgG-oligoclonal bands (OCB), and serum MOG-IgG. The patient initially presented with loss of visual acuity and later experienced bilateral optic neuritis, eventually leading to a diagnosis of progressive MS. Despite various treatments, the patient's condition continued to deteriorate, and retrospective analysis revealed the presence of MOG-IgG antibodies in the serum.

• 1
  The patient was MOG-IgG-positive and experienced progressive neurological deterioration after two episodes of ON.
• 2
  MRI scans revealed new lesions in the brain, cerebellum, brainstem, and spinal cord, indicating progressive demyelination.
• 3
  The case highlights the atypical presentation of MOG-IgG-related entities, which are typically considered part of NMOSD but can sometimes resemble MS.