Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 641-650 of 730 results
Pharmaceuticals, 2017 • October 24, 2017
This study demonstrates that systemic administration of IL-4 promotes neuroprotection after SCI, as evidenced by an increase in motor neurons and oligodendrocytes. IL-4 treatment led to a reduction in...
KEY FINDING: Systemic IL-4 administration increased the anti-inflammatory cytokine IL-10 in the serum of rats with spinal cord injuries.
Brain Sci., 2018 • February 18, 2018
Neuron-specific enolase (NSE) plays a complex role in neuroinflammation, neurodegeneration, and neuroprotection, especially in conditions like spinal cord injury (SCI) and various neurodegenerative di...
KEY FINDING: NSE can act as a biomarker for neuronal stress and has prognostic potential for neurological disorders.
Journal of Experimental Medicine, 2018 • February 1, 2018
This study demonstrates that γδ T cells, especially Vγ4 γδ T cells, are recruited at the injury site during the early phase after SCI, which impairs functional recovery. IFN-γ secreted by Vγ4 γδ T cel...
KEY FINDING: Depletion or inactivation of γδ T cells, particularly the Vγ4 subtype, in mice leads to improved functional recovery after spinal cord injury (SCI).
Frontiers in Neurology, 2017 • December 15, 2017
This study provides evidence from human data that an enhanced TGF-β system activity may critically mediate the imbalance of neuroregenerative and neurodegenerative processes in ALS. The analysis of pa...
KEY FINDING: ALS patients exhibit enhanced circulating TGF-β1 serum levels.
PLoS Medicine, 2008 • August 19, 2008
This study investigates the role of chondroitin sulfate proteoglycan (CSPG) in spinal cord repair, challenging the common belief that it's solely detrimental. The research hypothesizes and demonstrate...
KEY FINDING: Immediate inhibition of CSPG synthesis after spinal cord injury impairs functional motor recovery and increases tissue loss, indicating a beneficial role for CSPG during the acute phase.
Journal of Neuroinflammation, 2018 • April 2, 2018
This study identifies inhibitory mechanisms for CSPGs and their receptors, LAR and PTPσ, in modulating the immune response after SCI. Modulation of CSPG signaling with ILP and ISP treatment drives an ...
KEY FINDING: Blocking LAR and PTPσ reduces the population of classically activated M1 microglia/macrophages, while promoting alternatively activated M2 microglia/macrophages and T regulatory cells.
Neurotherapeutics, 2018 • May 1, 2018
The review discusses the role of glial and inflammatory cells after SCI and therapeutic strategies targeting these cells to modulate scarring and inflammation. SCI activates resident astrocytes and re...
KEY FINDING: SCI triggers diverse glial activation and cellular recruitment with complex downstream effects on neuronal function.
Neural Regen Res, 2018 • April 1, 2018
This study investigated the effects of combining macrophage depletion with Schwann cell transplantation in a rat model of contusive spinal cord injury. The rationale was to reduce inflammation and imp...
KEY FINDING: The combined treatment of macrophage depletion and Schwann cell transplantation significantly reduced cyst volumes in the injured spinal cord compared to Schwann cell transplantation alone.
Neurotherapeutics, 2018 • May 4, 2018
Spinal cord injury (SCI) leads to tissue loss, inflammation, and functional impairments. Macrophages contribute to the inflammatory response, while mesenchymal stem cells (MSCs) have shown potential f...
KEY FINDING: MSCs secrete factors that promote neuroprotection, angiogenesis, and stabilization of the spinal cord-blood barrier, contributing to anatomical repair and functional recovery after spinal cord injury.
Molecular Therapy, 2018 • July 1, 2018
The study investigates the effect of localized immunomodulation using lentiviral delivery of IL-10 and IL-4 from a multichannel PLG bridge on nerve regeneration after spinal cord injury. The hypothesi...
KEY FINDING: Induced IL-10 and IL-4 expression decreased expression of pro-inflammatory genes and increased pro-regenerative genes relative to control. The anti-inflammatory factors led to increased numbers of axons and myelination.