Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 661-670 of 730 results
Cellular & Molecular Immunology, 2019 • March 15, 2019
Neuroinflammation, a hallmark of neurological disorders, can be both detrimental and beneficial to the central nervous system (CNS). While excessive inflammation can cause injury and death to neural e...
KEY FINDING: Neuroinflammation promotes neurogenesis by influencing the formation of new neurons, with T lymphocytes playing a role in learning-induced hippocampal neurogenesis.
Acta Neuropathol, 2019 • May 1, 2019
Macrophages play a central role in all phases of spinal cord injury pathogenesis, mediating both harmful and beneficial effects. The origin of macrophages, whether from the spleen, bone marrow, or loc...
KEY FINDING: Splenic macrophages are a major source of pro-inflammatory macrophages during the acute phase of SCI, while bone marrow-derived macrophages may contribute to repopulation of the injury site with anti-inflammatory macrophages.
Scientific Reports, 2019 • March 7, 2019
This study investigates the role of mouse mast cell protease 4 (mMCP4) in scar development after spinal cord injury (SCI). The absence of mMCP4 in knockout mice results in exacerbated scar formation a...
KEY FINDING: mMCP4−/− mice showed decreased locomotor performance and increased scar formation at the lesion site after SCI.
Cell Death & Differentiation, 2019 • April 5, 2019
The study examined the impact of Zika virus (ZIKV) on human neural progenitor cells (NPCs) derived from different brain regions, finding that ZIKV infects these cells similarly, leading to growth arre...
KEY FINDING: ZIKV efficiently infects human NPCs from various brain regions (forebrain dorsal, forebrain ventral, hindbrain, and spinal cord) derived from human embryonic stem cells.
Evidence-Based Complementary and Alternative Medicine, 2019 • March 14, 2019
This study investigates the effects of Alpinia oxyphylla (AO-1) on experimental autoimmune encephalomyelitis (EAE) in mice, a model for multiple sclerosis (MS). The results demonstrate that AO-1 ameli...
KEY FINDING: AO-1 significantly reduced EAE symptoms in mice, as evidenced by decreased EAE scores and attenuated neurological disorders.
Sci. Adv., 2019 • May 15, 2019
The study investigates the role of macrophages and the interferon regulatory factor 8 (IRF8) in the spontaneous healing process after spinal cord injury (SCI). The research reveals that macrophages mi...
KEY FINDING: IRF8 expression is increased in the spinal cord after SCI.
Cells, 2019 • May 21, 2019
The study established a ventral root crush model in mice to analyze motoneuron loss, glial responses, and synaptic changes. It found that neuronal survival decreased over time in both WT and β2m KO mi...
KEY FINDING: Ventral root crush leads to time-dependent motoneuron loss in both WT and β2m KO mice.
Brain Behav Immun, 2019 • October 1, 2019
This study investigates the therapeutic potential of targeting TNFR2 in an EAE mouse model of MS. The results demonstrate that systemic administration of a TNFR2 agonist alleviates sensory and motor d...
KEY FINDING: Systemic administration of a TNFR2 agonist alleviates sensory and motor deficits in EAE, indicating that protective responses via Tregs and/or CNS-resident cells exceed potential pathogenic responses.
Sci Immunol, 2019 • July 5, 2019
This study investigates the migratory behavior of human skin-resident memory T cells (TRM), challenging the concept of strict tissue compartmentalization. The research identifies a circulating populat...
KEY FINDING: Human skin CD4+ TRM can downregulate CD69 and exit the skin.
PNAS, 2019 • July 8, 2019
This study investigates the potential for reprogramming circulating innate immune cells through nanoparticle administration to enhance functional regeneration following SCI. The nanoparticles (500 nm ...
KEY FINDING: Intravenously administered nanoparticles are internalized by circulating monocytes and neutrophils, reprogramming these cells based on their physicochemical properties.