Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 631-640 of 730 results
Journal of Neuroinflammation, 2016 • September 22, 2016
This study examined the expression of the Nogo receptor complex (NgR, LINGO-1, p75, and TROY) in a mouse model of experimental autoimmune encephalomyelitis (EAE), mimicking multiple sclerosis, to unde...
KEY FINDING: NgR was found to be expressed on neurons, within inflammatory foci, and colocalized with axonal growth cones, suggesting a role in axonal guidance and clearance during demyelination.
Brain, 2016 • October 25, 2016
This study demonstrates that IL4I1, an enzyme secreted by alternatively activated macrophages, plays a crucial role in augmenting CNS remyelination and axonal protection by modulating T cell-driven in...
KEY FINDING: IL4I1 is upregulated at the onset of inflammation resolution and remyelination in mouse central nervous system lesions.
Journal of Cellular and Molecular Medicine, 2017 • May 1, 2017
This review explores the immune pathophysiology of SCI, with a focus on inflammation dominated by macrophages in the secondary damage phase. The injured spinal cord microenvironment favors M1 polariza...
KEY FINDING: Macrophages in the injured spinal cord are heterogeneous, consisting of CNS-resident microglia-derived macrophages and bone marrow-derived macrophages, which differ in location and function.
Bioengineering & Translational Medicine, 2016 • January 1, 2016
This study investigates the use of multiple-channel bridges to deliver IL-10-encoding lentivirus to the site of spinal cord injury in order to modulate the inflammatory response and promote regenerati...
KEY FINDING: IL-10 gene delivery from bridges reduces neutrophil infiltration at both day 7 and day 28 post-injury, suggesting a sustained anti-inflammatory effect.
Spinal Cord Series and Cases, 2016 • September 15, 2016
This case report highlights the diagnostic challenges in HIV-vacuolar myelopathy, emphasizing that a negative MRI scan does not exclude the condition. The importance of assessing both peripheral and c...
KEY FINDING: A negative or unspecific MRI scan does not rule out HIV-related myelopathy in HIV-positive patients with myelopathy symptoms.
The Journal of Neuroscience, 2017 • March 1, 2017
This study used the RiboTag method to obtain the first macrophage-specific transcriptional profile after SCI. Data indicate that macrophages acutely after SCI (3 d) are enriched in genes associated wi...
KEY FINDING: Macrophages acutely after SCI (3 d) are enriched in genes associated with cell migration and cytokine signaling.
Mediators of Inflammation, 2017 • January 19, 2017
Damage to the central nervous system (CNS) is one of the leading causes of morbidity and mortality in elderly, as repair after lesions or neurodegenerative disease usually fails because of the limited...
KEY FINDING: Stimulation of inflammation has proven to be one of the pivotal factors to induce a regenerative response in mammalian axonal regeneration models.
eLife, 2017 • May 16, 2017
The study examines cell-based inflammation in the African spiny mouse, a mammalian model of epimorphic regeneration, to test the hypothesis that macrophages are necessary for regeneration. The researc...
KEY FINDING: The study found that both species, Acomys cahirinus (regenerating) and Mus musculus (scarring), exhibited an acute inflammatory response, with scarring characterized by stronger myeloperoxidase activity.
International Journal of Molecular Sciences, 2017 • July 1, 2017
This study evaluates a dual in vitro immunomodulation potency assay to monitor the immunomodulatory potential of MSC-derived EVs. The assay reproducibly reports the inhibitory effect of MSCs on induce...
KEY FINDING: MSC-derived EVs inhibit phytohemagglutinin (PHA)-stimulated T-cell proliferation in a dose-dependent manner, comparable to MSCs.
Nat Protoc, 2017 • October 1, 2017
The study presents a detailed protocol for generating humanized bone marrow ossicles in mice to improve the study of human hematopoiesis and leukemia. This method involves in situ differentiation of b...
KEY FINDING: The ossicles allow for accelerated and superior engraftment of primary patient-derived acute myeloid leukemia (AML) and other hematologic malignancies such as myelofibrosis (MF) in mice.