Immunology Research

KEY FINDING: Increased expression of caveolin-1 was found in serum and spinal cord tissues of wild-type mice with active encephalomyelitis, correlating with disease incidence and severity.

KEY FINDING: Humanized ossicles exhibit robust engraftment of normal human hematopoietic stem and progenitor cells.

KEY FINDING: TLR4 mutant mice exhibited greater functional recovery and increased p75NTR and neurofilament protein expression compared to wild-type mice.

KEY FINDING: FMD cycles reduced disease severity in mice with experimental autoimmune encephalomyelitis (EAE), an animal model for MS, and reversed symptoms in some animals.

KEY FINDING: Intrathecal administration of DcR3.Fc significantly improved locomotor function and reduced secondary injury with a smaller wound cavity and increased myelin sparing at the lesion site.

KEY FINDING: Quercetin treatment improved functional recovery in rats after SCI, as evidenced by significantly higher BBB scores and elevated rump height compared to the control group.

KEY FINDING: Allergic sensitization led to a reduction in the number of Iba1+ microglia in the granular layer (GL) and subgranular zone (SGZ) of the hippocampal dentate gyrus.

KEY FINDING: Biomaterial scaffolds can provide physical guidance for regenerating axons and limit leukocyte infiltration, but their interactions with immune cells are complex and affected by physical and chemical properties.

KEY FINDING: BMP-7 increases VEGF levels, which promote angiogenesis, essential for bone healing.

KEY FINDING: SCI triggers systemic inflammatory responses, marked by increased immune cells and pro-inflammatory mediators, leading to inflammation in secondary organs.