Nogo receptor complex expression dynamics in the inflammatory foci of central nervous system experimental autoimmune demyelination

This study investigates the role of the Nogo receptor complex in the inflammatory environment of autoimmune demyelination, using a mouse model of multiple sclerosis. The researchers focused on how the receptor and its associated molecules, LINGO-1, p75, and TROY, change over time within the inflammatory sites. The study found that the expression of these molecules varies depending on the phase of the disease. Specifically, NgR, LINGO-1, and TROY were increased in the acute phase, while LINGO-1 and p75 were more prominent in the chronic phase. These findings suggest that the Nogo receptor complex may have a role in regulating inflammation and axonal growth during autoimmune demyelination, potentially influencing the disease's progression.

• 1
  NgR was found to be expressed on neurons, within inflammatory foci, and colocalized with axonal growth cones, suggesting a role in axonal guidance and clearance during demyelination.
• 2
  LINGO-1 and TROY are mainly acute-phase responders, expressed by macrophages/microglia, while p75 is expressed in growth cones during the chronic phase.
• 3
  NgR is selectively expressed by M2 macrophages/microglia, implying a possible role in the repairing process during EAE.