Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 601-610 of 730 results
Journal of Neuroinflammation, 2025 • January 28, 2025
This study identifies heterogeneous nuclear ribonucleoprotein U (Hnrnpu) as a potential endogenous molecule that regulates astrocyte proliferation and the following scar formation. Inhibition of Hnrnp...
KEY FINDING: Hnrnpu promotes astrocyte reactivity. Inhibiting Hnrnpu suppresses astrocyte migration and alters expression of the genes associated with astrocyte reactivity in vitro.
Materials Today Bio, 2025 • January 23, 2025
The study introduces QLipTC@HDM, a multifunctional liposome hydrogel drug delivery system, to improve quercetin delivery for spinal cord injury (SCI) treatment. The system enhances drug solubility, re...
KEY FINDING: QLipTC@HDM induces M2 phenotype transformation in glial cells and in mice with SCI, thereby mitigating inflammation.
Journal of Nanobiotechnology, 2025 • January 22, 2025
This study investigates the application of decellularized tissue matrices (DSCM) hydrogels functionalized with extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) for spinal cor...
KEY FINDING: DSCM@EVs promote NSC differentiation into neurons and suppress astrocyte formation, alleviating SCI in mice.
Journal of Neuroinflammation, 2025 • March 5, 2025
This study uncovers the criticality of microglial location and abundance in orchestrating SCI repair, highlighting centripetal microglial dynamics as valuable targets for therapeutic intervention. The...
KEY FINDING: Decreased expression and perilesional distribution of CX3CL1 is the primary reason for the limited centripetal migration of microglia.
Cureus, 2025 • February 20, 2025
The microglial response to SCI is dynamic and multifaceted, involving a complex interplay of pro-inflammatory and anti-inflammatory processes that influence the outcome of the injury. The role of NF-k...
KEY FINDING: NF-kB signaling greatly influences how microglia respond to SCI, impacting inflammation, tissue damage, and the potential for healing.
Journal of Clinical Laboratory Analysis, 2015 • January 1, 2015
This retrospective study compared three different test systems (ELISA, solid-phase assay, and LCT) for detecting platelet antibodies in 1,234 patient samples. The results showed significant divergence...
KEY FINDING: Platelet antibodies were detected in 29.7% of the 1,234 samples tested.
Neurobiol Dis., 2015 • February 1, 2015
This study investigates the role of macrophages in fibrotic scar formation after spinal cord injury (SCI). The research demonstrates that hematogenous macrophages (hMΦ), not microglia, are primarily a...
KEY FINDING: Hematogenous macrophages, rather than microglia, are predominantly present in the fibrotic scar after spinal cord injury.
The Journal of Neuroscience, 2015 • January 21, 2015
This study investigates the potential of using clinically approved medications to stimulate remyelination by activating monocytes, macrophages, and microglia. Amphotericin B (AmpB) was identified as a...
KEY FINDING: Amphotericin B (AmpB) activates monocytes, macrophages, and microglia through MyD88/TRIF signaling.
PLoS ONE, 2015 • March 17, 2015
The study aimed to investigate changes in adult neurogenesis during EAE using bioluminescence imaging (BLI) in DCX-luc mice and validate findings with immunohistochemistry. In vivo BLI showed an early...
KEY FINDING: In vivo bioluminescence imaging showed a marked increase in signal intensity after EAE induction, suggesting increased neurogenesis.
The Journal of Clinical Investigation, 2015 • April 1, 2015
The brain under immunological attack in MS reveals a coordinated molecular response involving various proteins and small molecules that provide protection and foster repair. Reduction of inflammation ...
KEY FINDING: Protective cytokines like IL-10 and IL-27, produced by immune cells migrating into the brain or by resident glia and neurons, attenuate inflammation in MS.