Mesenchymal Stem Cells in the Pathogenesis and Therapy of Autoimmune and Autoinflammatory Diseases

Mesenchymal stem cells (MSCs) can control immune responses and help the body tolerate itself. They can potentially suppress the immune system to treat autoimmune and autoinflammatory diseases because they help regenerate tissues. MSCs are attracted to places where there is damage and inflammation. They can reduce inflammation and help the tissue heal itself. MSCs could be new treatments for serious autoimmune and autoinflammatory diseases, which currently only have treatments that manage the disease rather than cure it.

• 1
  MSCs are passive targets in inflammatory conditions, becoming impaired and losing their immunomodulatory function.
• 2
  Clinical application of MSCs has shown potential in treating multiple diseases, including rheumatoid arthritis, systemic lupus erythematosus, myocardial infarction, liver cirrhosis, spinal cord injury, multiple sclerosis, and COVID-19 pneumonia.
• 3
  Paracrine activity of MSCs regulates immune cell biology, promotes angiogenesis, and suppresses fibrotic remodelling.